Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68358
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acan
Name: aggrecan
Acc ID: CHEBI:20993
Term: aldehydo-D-glucosamine
Definition: The open-chain form of D-glucosamine.
Chemical ID: MESH:D005944
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acanmultiple interactionsEXP 6480464CTDGlucosamine inhibits the reaction [IL1B results in decreased expression of ACAN mRNA]PMID:17109745
Acanaffects expressionISOACAN (Homo sapiens)6480464CTDGlucosamine analog affects the expression of ACAN mRNAPMID:17337215
Acandecreases expressionISOACAN (Homo sapiens)6480464CTDGlucosamine analog results in decreased expression of ACAN mRNAPMID:16300972
Acanincreases expressionISOACAN (Homo sapiens)6480464CTDGlucosamine analog results in increased expression of ACAN protein; Glucosamine results in increased expression of ACAN mRNA; Glucosamine results in increased expression of ACAN proteinPMID:12801482 PMID:17337215 PMID:18321735
Acanincreases expressionISOAcan (Mus musculus)6480464CTDGlucosamine results in increased expression of ACAN mRNAPMID:16872674
Acanmultiple interactionsISOACAN (Homo sapiens)6480464CTDGlucosamine analog affects the reaction [IL1B results in decreased expression of ACAN mRNA]; Glucosamine inhibits the reaction [IL1B protein results in decreased expression of ACAN mRNA]; Glucosamine results in decreased cleavage of and results in decreased secretion of ACAN proteinPMID:17337215 PMID:18321735 PMID:19909832
Go Back to source page   Continue to Ontology report