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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68353
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr5a2
Name: nuclear receptor subfamily 5, group A, member 2
Acc ID: CHEBI:43602
Term: obeticholic acid
Definition: A dihydroxy-5beta-cholanic acid that is chenodeoxycholic acid carrying an additional ethyl substituent at the 6alpha-position. A semi-synthetic bile acid which acts as a farnesoid X receptor agonist and is used for treatment of primary biliary cholangitis.
Chemical ID: MESH:C464660
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr5a2decreases expressionISONR5A2 (Homo sapiens)6480464CTDobeticholic acid results in decreased expression of NR5A2 mRNAPMID:27939613
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