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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:obeticholic acid
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Accession:CHEBI:43602 term browser browse the term
Definition:A dihydroxy-5beta-cholanic acid that is chenodeoxycholic acid carrying an additional ethyl substituent at the 6alpha-position. A semi-synthetic bile acid which acts as a farnesoid X receptor agonist and is used for treatment of primary biliary cholangitis.
Synonyms:exact_synonym: 6alpha-ethyl-3alpha,7alpha-dihydroxy-5beta-cholan-24-oic acid
 related_synonym: (3alpha,5beta,6alpha,7alpha)-6-ethyl-3,7-dihydroxycholan-24-oic acid;   6-ECDCA;   6-Ethyl-CDCA;   6-Ethylchenodeoxycholic acid;   6alpha-Ethyl-chenodeoxycholic acid;   6alpha-ethylchenodeoxycholic acid;   Formula=C26H44O4;   INT 747;   INT747;   InChI=1S/C26H44O4/c1-5-17-21-14-16(27)10-12-26(21,4)20-11-13-25(3)18(15(2)6-9-22(28)29)7-8-19(25)23(20)24(17)30/h15-21,23-24,27,30H,5-14H2,1-4H3,(H,28,29)/t15-,16-,17-,18-,19+,20+,21+,23+,24-,25-,26-/m1/s1;   InChIKey=ZXERDUOLZKYMJM-ZWECCWDJSA-N;   Ocaliva;   SMILES=C1[C@@]2([C@]3(CC[C@]4([C@]([C@@]3([C@@H]([C@@H]([C@@]2(C[C@@H](C1)O)[H])CC)O)[H])(CC[C@@]4([C@@H](CCC(O)=O)C)[H])[H])C)[H])C
 alt_id: CHEBI:132971;   CHEBI:41467;   CHEBI:43599;   MESH:C464660
 xref: CAS:459789-99-2;   Drug_Central:5155;   KEGG:C15636;   KEGG:D09360
 xref_mesh: MESH:C464660
 xref: PDBeChem:CHC;   PMID:22406511;   PMID:23593273;   PMID:24382005;   PMID:24623154;   PMID:25329562;   PMID:25421586;   PMID:25468160;   PMID:25500425;   PMID:25592258;   PMID:25726736;   PMID:25753820;   PMID:25864227;   PMID:26136168;   PMID:26169860;   PMID:26169861;   PMID:26169862;   PMID:26549695;   PMID:26723896;   PMID:26811456;   PMID:26812075;   PMID:27109453;   PMID:27406083;   PMID:27425465;   PMID:27468093;   PMID:27475255;   Reaxys:9238543;   Wikipedia:Obeticholic_acid


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obeticholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin decreases expression ISO obeticholic acid results in decreased expression of A2M mRNA CTD PMID:27939613 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786 		JBrowse link
G Abca1 ATP binding cassette subfamily A member 1 decreases expression ISO obeticholic acid results in decreased expression of ABCA1 mRNA CTD PMID:27939613 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
increases expression		 ISO
EXP		 obeticholic acid promotes the reaction [PRMT1 protein binds to ABCB11 promoter]
obeticholic acid results in increased expression of ABCB11 mRNA
obeticholic acid inhibits the reaction [Isoniazid results in decreased expression of ABCB11 mRNA]; obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of ABCB11 mRNA]
[obeticholic acid co-treated with 1-Naphthylisothiocyanate] results in increased expression of ABCB11 protein; obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in decreased expression of ABCB11 protein]; obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 mRNA]; obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 protein]
Obeticholic acid inhibits the reaction [ethanol decreases expression of Abcb11 protein in liver]		 CTD
RGD		 PMID:15644430 PMID:15911693 PMID:27255380 PMID:27939613 PMID:29660435 More... RGD:15036816 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 multiple interactions
increases expression		 EXP
ISO		 obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of ABCB4 mRNA]
obeticholic acid results in increased expression of ABCB4 mRNA		 CTD PMID:15644430 PMID:27255380 PMID:27939613 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
increases expression		 EXP
ISO		 obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of ABCC2 mRNA]
obeticholic acid results in increased expression of ABCC2 mRNA
[obeticholic acid co-treated with 1-Naphthylisothiocyanate] results in increased expression of ABCC2 protein; [triptolide co-treated with Lipopolysaccharides co-treated with obeticholic acid] results in increased expression of ABCC2 mRNA; NR1H4 promotes the reaction [obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC2 mRNA]]; obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC2 mRNA]; obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC2 protein]		 CTD PMID:15644430 PMID:27255380 PMID:29660435 PMID:36328986 PMID:36787806 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions EXP
ISO		 obeticholic acid inhibits the reaction [Isoniazid results in decreased expression of ABCC3 mRNA]
[obeticholic acid co-treated with 1-Naphthylisothiocyanate] results in increased expression of ABCC3 protein		 CTD PMID:32673658 PMID:36787806 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions ISO [obeticholic acid co-treated with 1-Naphthylisothiocyanate] results in increased expression of ABCC4 protein CTD PMID:36787806 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 decreases expression ISO obeticholic acid results in decreased expression of ABCG1 mRNA CTD PMID:27939613 NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948 		JBrowse link
G Acaa1a acetyl-CoA acyltransferase 1A increases expression ISO obeticholic acid results in increased expression of ACAA1 mRNA CTD PMID:27939613 NCBI chr 8:119,079,401...119,088,626
Ensembl chr 8:119,079,775...119,088,624 		JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 increases expression ISO obeticholic acid results in increased expression of ACAA2 mRNA CTD PMID:27939613 NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha decreases expression ISO obeticholic acid results in decreased expression of ACACA mRNA CTD PMID:27939613 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Acot9 acyl-CoA thioesterase 9 increases expression ISO obeticholic acid results in increased expression of ACOT9 mRNA CTD PMID:27939613 NCBI chr  X:40,073,197...40,123,573
Ensembl chr  X:40,064,810...40,123,559 		JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression ISO obeticholic acid results in increased expression of ACOX1 mRNA CTD PMID:26655953 PMID:27939613 NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Acox2 acyl-CoA oxidase 2 increases expression ISO obeticholic acid results in increased expression of ACOX2 mRNA CTD PMID:27939613 NCBI chr15:16,660,584...16,692,160
Ensembl chr15:16,660,272...16,692,160 		JBrowse link
G Acox3 acyl-CoA oxidase 3, pristanoyl increases expression ISO obeticholic acid results in increased expression of ACOX3 mRNA CTD PMID:27939613 NCBI chr14:75,133,986...75,176,767
Ensembl chr14:75,094,676...75,176,205 		JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 decreases expression ISO obeticholic acid results in decreased expression of ACSL1 mRNA CTD PMID:27939613 NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541 		JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 increases expression ISO obeticholic acid results in increased expression of ACSL4 mRNA CTD PMID:27939613 NCBI chr  X:105,942,794...106,006,573
Ensembl chr  X:105,942,799...106,006,427 		JBrowse link
G Acsl5 acyl-CoA synthetase long-chain family member 5 increases expression ISO obeticholic acid results in increased expression of ACSL5 mRNA CTD PMID:27939613 NCBI chr 1:254,289,513...254,336,608
Ensembl chr 1:254,292,521...254,336,607 		JBrowse link
G Acsl6 acyl-CoA synthetase long-chain family member 6 increases expression ISO obeticholic acid results in increased expression of ACSL6 mRNA CTD PMID:27939613 NCBI chr10:38,439,914...38,501,182
Ensembl chr10:38,440,080...38,498,757 		JBrowse link
G Adamtsl2 ADAMTS-like 2 decreases expression ISO obeticholic acid results in decreased expression of ADAMTSL2 mRNA CTD PMID:27939613 NCBI chr 3:10,397,774...10,434,557
Ensembl chr 3:10,404,626...10,434,554 		JBrowse link
G Adcy1 adenylate cyclase 1 increases expression ISO obeticholic acid results in increased expression of ADCY1 mRNA CTD PMID:27939613 NCBI chr14:81,911,240...82,020,594
Ensembl chr14:81,911,099...82,028,969 		JBrowse link
G Adh1c alcohol dehydrogenase 1C (class I), gamma polypeptide decreases expression ISO obeticholic acid results in decreased expression of ADH1C mRNA CTD PMID:27939613 NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892 		JBrowse link
G Agpat2 1-acylglycerol-3-phosphate O-acyltransferase 2 decreases expression ISO obeticholic acid results in decreased expression of AGPAT2 mRNA CTD PMID:27939613 NCBI chr 3:9,416,837...9,428,567
Ensembl chr 3:9,416,843...9,428,371 		JBrowse link
G Agpat5 1-acylglycerol-3-phosphate O-acyltransferase 5 decreases expression ISO obeticholic acid results in decreased expression of AGPAT5 mRNA CTD PMID:27939613 NCBI chr16:70,939,480...70,985,745
Ensembl chr16:70,943,135...70,985,560 		JBrowse link
G Akr1d1 aldo-keto reductase family 1, member D1 decreases expression ISO obeticholic acid results in decreased expression of AKR1D1 mRNA CTD PMID:27939613 NCBI chr 4:66,154,246...66,187,505
Ensembl chr 4:66,154,248...66,186,372 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases expression
decreases phosphorylation		 ISO obeticholic acid inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of AKT1 protein]; obeticholic acid promotes the reaction [Dietary Fats results in decreased phosphorylation of AKT1 protein]
obeticholic acid results in decreased expression of AKT1 mRNA
obeticholic acid results in decreased phosphorylation of AKT1 protein		 CTD PMID:27865854 PMID:27939613 PMID:35267068 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 decreases expression ISO obeticholic acid results in decreased expression of AKT2 mRNA CTD PMID:27939613 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Alb albumin decreases expression
multiple interactions		 ISO
EXP		 obeticholic acid results in decreased expression of ALB mRNA
[Dietary Fats co-treated with obeticholic acid] results in decreased expression of ALB mRNA; [Dietary Fats co-treated with obeticholic acid] results in decreased expression of ALB protein		 CTD PMID:27939613 PMID:35267068 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Aldoa aldolase, fructose-bisphosphate A decreases expression ISO obeticholic acid results in decreased expression of ALDOA mRNA CTD PMID:27939613 NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182 		JBrowse link
G Aldob aldolase, fructose-bisphosphate B decreases expression ISO obeticholic acid results in decreased expression of ALDOB mRNA CTD PMID:27939613 NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116 		JBrowse link
G Aldoc aldolase, fructose-bisphosphate C increases expression ISO obeticholic acid results in increased expression of ALDOC mRNA CTD PMID:27939613 NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066 		JBrowse link
G Amn amnion associated transmembrane protein decreases expression ISO obeticholic acid results in decreased expression of AMN mRNA CTD PMID:27939613 NCBI chr 6:130,311,372...130,318,815
Ensembl chr 6:130,311,372...130,318,815 		JBrowse link
G Apoa1 apolipoprotein A1 decreases expression ISO obeticholic acid results in decreased expression of APOA1 mRNA CTD PMID:27939613 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Apoa2 apolipoprotein A2 increases expression ISO obeticholic acid results in increased expression of APOA2 mRNA CTD PMID:27939613 NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355 		JBrowse link
G Apob apolipoprotein B increases expression ISO obeticholic acid results in increased expression of APOB mRNA CTD PMID:27939613 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497 		JBrowse link
G Apoc2 apolipoprotein C2 increases expression ISO obeticholic acid results in increased expression of APOC2 mRNA CTD PMID:27939613 NCBI chr 1:79,329,429...79,334,397
Ensembl chr 1:79,329,428...79,334,476 		JBrowse link
G Apoc3 apolipoprotein C3 decreases expression ISO obeticholic acid results in decreased expression of APOC3 mRNA CTD PMID:27939613 NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583 		JBrowse link
G Apoe apolipoprotein E decreases expression ISO obeticholic acid results in decreased expression of APOE mRNA CTD PMID:27939613 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Aspg asparaginase decreases expression ISO obeticholic acid results in decreased expression of ASPG mRNA CTD PMID:27939613 NCBI chr 6:131,176,727...131,196,268
Ensembl chr 6:131,176,874...131,196,268 		JBrowse link
G Atg5 autophagy related 5 multiple interactions ISO obeticholic acid inhibits the reaction [[Dietary Fats co-treated with Dextran Sulfate] results in decreased expression of ATG5 mRNA] CTD PMID:35439472 NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Bad BCL2-associated agonist of cell death decreases expression ISO obeticholic acid results in decreased expression of BAD mRNA CTD PMID:27939613 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions		 ISO obeticholic acid results in increased expression of BCL2 mRNA
[Dietary Fats co-treated with obeticholic acid] results in decreased expression of BCL2 protein		 CTD PMID:27939613 PMID:35267068 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bid BH3 interacting domain death agonist decreases expression ISO obeticholic acid results in decreased expression of BID mRNA CTD PMID:27939613 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression ISO obeticholic acid results in decreased expression of BIRC3 mRNA CTD PMID:27939613 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G C5ar2 complement C5a receptor 2 decreases expression ISO obeticholic acid results in decreased expression of C5AR2 mRNA CTD PMID:27939613 NCBI chr 1:76,930,381...76,945,432
Ensembl chr 1:76,930,383...76,959,517 		JBrowse link
G Car14 carbonic anhydrase 14 increases expression ISO obeticholic acid results in increased expression of CA14 mRNA CTD PMID:27939613 NCBI chr 2:183,442,263...183,449,231
Ensembl chr 2:183,441,667...183,449,693 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO		 obeticholic acid promotes the reaction [Cycloheximide results in increased activity of CASP3 protein]
obeticholic acid inhibits the reaction [Dietary Fats results in increased expression of CASP3 protein]		 CTD PMID:15860571 PMID:26655953 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp4 caspase 4 multiple interactions ISO obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in increased cleavage of CASP4 protein] CTD PMID:36328986 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092 		JBrowse link
G Casp8 caspase 8 increases expression ISO obeticholic acid results in increased expression of CASP8 mRNA CTD PMID:27939613 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO obeticholic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of CCL2 mRNA] CTD PMID:27865854 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in increased expression of CCNB1 protein] CTD PMID:29660435 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO obeticholic acid inhibits the reaction [[Dietary Fats co-treated with Dextran Sulfate] results in decreased expression of CCND1 protein]; obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in increased expression of CCND1 protein] CTD PMID:29660435 PMID:35439472 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccs copper chaperone for superoxide dismutase decreases expression ISO obeticholic acid results in decreased expression of CCS mRNA CTD PMID:27939613 NCBI chr 1:202,113,792...202,134,931
Ensembl chr 1:202,113,804...202,134,915 		JBrowse link
G Cd14 CD14 molecule decreases expression ISO obeticholic acid results in decreased expression of CD14 mRNA CTD PMID:27939613 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261 		JBrowse link
G Cldn5 claudin 5 multiple interactions ISO obeticholic acid inhibits the reaction [Methamphetamine results in decreased expression of CLDN5 protein] CTD PMID:36720452 NCBI chr11:82,212,822...82,214,248
Ensembl chr11:82,211,475...82,214,992 		JBrowse link
G Clic4 chloride intracellular channel 4 increases expression ISO obeticholic acid results in increased expression of CLIC4 mRNA CTD PMID:27939613 NCBI chr 5:147,453,702...147,513,455
Ensembl chr 5:147,453,712...147,513,452 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression
multiple interactions		 EXP
ISO		 obeticholic acid results in decreased expression of COL1A1 mRNA; obeticholic acid results in decreased expression of COL1A1 protein
obeticholic acid inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]
obeticholic acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of COL1A1 mRNA]		 CTD PMID:15860571 PMID:15980055 PMID:27939613 PMID:30745416 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions
increases expression		 ISO
EXP		 obeticholic acid promotes the reaction [Palmitic Acid results in increased expression of CPT1A mRNA]
obeticholic acid results in increased expression of CPT1A mRNA
obeticholic acid inhibits the reaction [Ethanol results in decreased expression of CPT1A protein]
Obeticholic acid inhibits the reaction [ethanol decreases expression of CPT1a mRNA and protein in liver]
obeticholic acid results in increased expression of CPT1A protein		 CTD
RGD		 PMID:26655953 PMID:27939613 PMID:27939985 PMID:32738331 PMID:27939985 RGD:15036816 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 increases expression ISO obeticholic acid results in increased expression of CPT2 mRNA CTD PMID:27939613 NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095 		JBrowse link
G Crct1 cysteine-rich C-terminal 1 decreases expression ISO obeticholic acid results in decreased expression of CRCT1 mRNA CTD PMID:27939613 NCBI chr 2:178,633,789...178,635,274
Ensembl chr 2:178,634,092...178,634,394 		JBrowse link
G Creb3l1 cAMP responsive element binding protein 3-like 1 decreases expression ISO obeticholic acid results in decreased expression of CREB3L1 mRNA CTD PMID:27939613 NCBI chr 3:77,952,589...77,993,513
Ensembl chr 3:77,952,540...77,993,456 		JBrowse link
G Creb3l3 cAMP responsive element binding protein 3-like 3 increases expression ISO obeticholic acid results in increased expression of CREB3L3 mRNA CTD PMID:27939613 NCBI chr 7:8,622,614...8,631,053
Ensembl chr 7:8,622,614...8,631,048 		JBrowse link
G Crp C-reactive protein decreases expression ISO obeticholic acid results in decreased expression of CRP mRNA CTD PMID:27939613 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO obeticholic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of CXCL2 mRNA] CTD PMID:27865854 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO obeticholic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of CXCL1 mRNA] CTD PMID:27865854 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases expression ISO obeticholic acid results in decreased expression of CYP19A1 mRNA CTD PMID:27939613 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression ISO obeticholic acid results in decreased expression of CYP1A1 mRNA CTD PMID:27939613 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases expression
decreases activity		 ISO
EXP		 obeticholic acid inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of Acetaminophen]; obeticholic acid inhibits the reaction [CYP1A2 protein results in increased metabolism of Phenacetin]
obeticholic acid results in decreased expression of CYP1A2 mRNA
obeticholic acid results in decreased activity of CYP1A2 protein
[Dietary Fats co-treated with obeticholic acid] results in decreased expression of CYP1A2 mRNA; [Dietary Fats co-treated with obeticholic acid] results in decreased expression of CYP1A2 protein		 CTD PMID:27939613 PMID:35267068 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases expression ISO obeticholic acid results in decreased expression of CYP27A1 mRNA CTD PMID:27939613 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases expression ISO obeticholic acid results in decreased expression of CYP2C8 mRNA CTD PMID:27939613
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases expression ISO obeticholic acid results in increased expression of CYP2D6 mRNA CTD PMID:27939613 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression ISO obeticholic acid results in decreased expression of CYP2E1 mRNA CTD PMID:27939613 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp2r1 cytochrome P450, family 2, subfamily r, polypeptide 1 increases expression ISO obeticholic acid results in increased expression of CYP2R1 mRNA CTD PMID:27939613 NCBI chr 1:168,749,302...168,798,079
Ensembl chr 1:168,751,038...168,797,759 		JBrowse link
G Cyp2s1 cytochrome P450, family 2, subfamily s, polypeptide 1 decreases expression ISO obeticholic acid results in decreased expression of CYP2S1 mRNA CTD PMID:27939613 NCBI chr 1:81,309,948...81,325,303
Ensembl chr 1:81,310,451...81,325,303 		JBrowse link
G Cyp2u1 cytochrome P450, family 2, subfamily u, polypeptide 1 increases expression ISO obeticholic acid results in increased expression of CYP2U1 mRNA CTD PMID:27939613 NCBI chr 2:219,849,403...219,866,959
Ensembl chr 2:219,849,407...219,866,882 		JBrowse link
G Cyp39a1 cytochrome P450, family 39, subfamily a, polypeptide 1 decreases expression ISO obeticholic acid results in decreased expression of CYP39A1 mRNA CTD PMID:27939613 NCBI chr 9:17,230,455...17,306,775
Ensembl chr 9:17,230,455...17,306,775 		JBrowse link
G Cyp3a18 cytochrome P450, family 3, subfamily a, polypeptide 18 decreases expression ISO obeticholic acid results in decreased expression of CYP3A43 mRNA CTD PMID:27939613 NCBI chr12:8,880,509...8,930,382
Ensembl chr12:8,880,528...8,930,381 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
decreases activity
decreases expression		 ISO
EXP		 obeticholic acid inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone]; obeticholic acid inhibits the reaction [CYP3A4 protein results in increased metabolism of Testosterone]
obeticholic acid results in decreased activity of CYP3A4 protein
obeticholic acid results in decreased expression of CYP3A4 mRNA
obeticholic acid results in decreased expression of CYP3A2 mRNA		 CTD PMID:27939613 PMID:35267068 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 decreases expression EXP obeticholic acid results in decreased expression of CYP3A23-3A1 mRNA CTD PMID:35267068 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 decreases expression ISO obeticholic acid results in decreased expression of CYP3A5 mRNA CTD PMID:27939613 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 decreases expression ISO obeticholic acid results in decreased expression of CYP4F12 mRNA CTD PMID:27939613 NCBI chr 7:12,010,850...12,022,497
Ensembl chr 7:12,010,852...12,022,046 		JBrowse link
G Cyp4f18 cytochrome P450, family 4, subfamily f, polypeptide 18 decreases expression ISO obeticholic acid results in decreased expression of CYP4F3 mRNA CTD PMID:27939613 NCBI chr16:17,763,543...17,804,944
Ensembl chr16:17,707,317...17,804,940 		JBrowse link
G Cyp4f39 cytochrome P450, family 4, subfamily f, polypeptide 39 decreases expression ISO obeticholic acid results in decreased expression of CYP4F22 mRNA CTD PMID:27939613 NCBI chr 7:11,426,806...11,505,553
Ensembl chr 7:11,433,371...11,536,181 		JBrowse link
G Cyp51 cytochrome P450, family 51 decreases expression ISO obeticholic acid results in decreased expression of CYP51A1 mRNA CTD PMID:27939613 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression
multiple interactions		 ISO
EXP		 obeticholic acid results in decreased expression of CYP7A1 mRNA
obeticholic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CYP7A1 protein]; obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in decreased expression of CYP7A1 protein]; obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP7A1 mRNA]
obeticholic acid decreases expression of CYP7a1 mRNA in liver in porcine serum induced model of cirrhosis in rat
Obeticholic acid inhibits the reaction [ethanol increases expression of Cyp7a1 protein in liver]
obeticholic acid inhibits the reaction [Isoniazid results in increased expression of CYP7A1 mRNA]		 CTD
RGD		 PMID:15644430 PMID:15911693 PMID:27939613 PMID:29660435 PMID:32673658 More... RGD:15045602, RGD:15036816 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression
increases expression
multiple interactions		 EXP
ISO		 obeticholic acid results in decreased expression of CYP8B1 mRNA
obeticholic acid results in increased expression of CYP8B1 mRNA
obeticholic acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP8B1 mRNA]		 CTD PMID:15644430 PMID:27939613 PMID:29660435 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO obeticholic acid inhibits the reaction [Dietary Fats results in increased expression of DDIT3 protein] CTD PMID:26655953 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 decreases expression ISO obeticholic acid results in decreased expression of DGAT2 mRNA CTD PMID:27939613 NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase increases expression ISO obeticholic acid results in increased expression of DHCR7 mRNA CTD PMID:27939613 NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055 		JBrowse link
G Dnajb11 DnaJ heat shock protein family (Hsp40) member B11 increases expression ISO obeticholic acid results in increased expression of DNAJB11 mRNA CTD PMID:27939613 NCBI chr11:78,151,750...78,168,259
Ensembl chr11:78,150,429...78,180,407 		JBrowse link
G Dpyd dihydropyrimidine dehydrogenase decreases expression ISO obeticholic acid results in decreased expression of DPYD mRNA CTD PMID:27939613 NCBI chr 2:206,609,043...207,474,982
Ensembl chr 2:206,609,122...207,474,982 		JBrowse link
G Dusp6 dual specificity phosphatase 6 increases expression ISO obeticholic acid results in increased expression of DUSP6 mRNA CTD PMID:27939613 NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185 		JBrowse link
G Ecsit ECSIT signaling integrator decreases expression ISO obeticholic acid results in decreased expression of ECSIT mRNA CTD PMID:27939613 NCBI chr 8:20,605,583...20,618,453
Ensembl chr 8:20,605,583...20,618,390 		JBrowse link
G Elovl1 ELOVL fatty acid elongase 1 increases expression ISO obeticholic acid results in increased expression of ELOVL1 mRNA CTD PMID:27939613 NCBI chr 5:131,961,478...131,965,961
Ensembl chr 5:131,961,322...131,965,958 		JBrowse link
G Elovl2 ELOVL fatty acid elongase 2 increases expression ISO obeticholic acid results in increased expression of ELOVL2 mRNA CTD PMID:27939613 NCBI chr17:23,544,598...23,584,855
Ensembl chr17:23,544,568...23,584,848 		JBrowse link
G Elovl6 ELOVL fatty acid elongase 6 decreases expression ISO obeticholic acid results in decreased expression of ELOVL6 mRNA CTD PMID:27939613 NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:218,063,804...218,171,186 		JBrowse link
G Elovl7 ELOVL fatty acid elongase 7 increases expression ISO obeticholic acid results in increased expression of ELOVL7 mRNA CTD PMID:27939613 NCBI chr 2:39,789,229...39,858,579
Ensembl chr 2:39,789,250...39,856,845 		JBrowse link
G Enc1 ectodermal-neural cortex 1 increases expression ISO obeticholic acid results in increased expression of ENC1 mRNA CTD PMID:27939613 NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713 		JBrowse link
G Eno1 enolase 1 decreases expression ISO obeticholic acid results in decreased expression of ENO1 mRNA CTD PMID:27939613 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336 		JBrowse link
G Eno3 enolase 3 increases expression ISO obeticholic acid results in increased expression of ENO3 mRNA CTD PMID:27939613 NCBI chr10:55,370,531...55,375,921
Ensembl chr10:55,366,975...55,375,921 		JBrowse link
G Fabp6 fatty acid binding protein 6 multiple interactions
increases expression		 ISO NR1H4 gene mutant form inhibits the reaction [obeticholic acid results in increased expression of FABP6 mRNA] CTD PMID:22918042 NCBI chr10:28,063,603...28,068,276
Ensembl chr10:28,063,603...28,068,282 		JBrowse link
G Fadd Fas associated via death domain increases expression ISO obeticholic acid results in increased expression of FADD mRNA CTD PMID:27939613 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions EXP Obeticholic acid inhibits the reaction [ethanol increases expression of Fas mRNA and protein in liver] RGD PMID:27939985 RGD:15036816 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fasn fatty acid synthase multiple interactions
decreases expression		 ISO obeticholic acid inhibits the reaction [Palmitic Acid results in increased expression of FASN mRNA]
obeticholic acid results in decreased expression of FASN mRNA
obeticholic acid inhibits the reaction [Ethanol results in increased expression of FASN protein]		 CTD PMID:26655953 PMID:27939613 PMID:27939985 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fbp1 fructose-bisphosphatase 1 decreases expression ISO obeticholic acid results in decreased expression of FBP1 mRNA CTD PMID:27939613 NCBI chr17:2,207,271...2,230,076
Ensembl chr17:2,208,031...2,230,071 		JBrowse link
G Fdps farnesyl diphosphate synthase decreases expression ISO obeticholic acid results in decreased expression of FDPS mRNA CTD PMID:27939613 NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776 		JBrowse link
G Fetub fetuin B increases expression ISO obeticholic acid results in increased expression of FETUB mRNA CTD PMID:27939613 NCBI chr11:78,082,158...78,093,022
Ensembl chr11:78,082,156...78,095,135 		JBrowse link
G Fgf19 fibroblast growth factor 19 increases expression
multiple interactions
increases secretion		 ISO
EXP		 obeticholic acid results in increased expression of FGF15 mRNA
NR1H4 gene mutant form inhibits the reaction [obeticholic acid results in increased expression of FGF15 mRNA]
obeticholic acid results in increased expression of FGF19 mRNA
obeticholic acid results in increased secretion of FGF19 protein
Obeticholic acid inhibits the reaction [ethanol decreases expression of FGF19 protein in liver and intestine]		 CTD
RGD		 PMID:22918042 PMID:27939613 PMID:27939985 RGD:15036816 NCBI chr 1:200,056,526...200,060,980
Ensembl chr 1:200,056,644...200,060,287 		JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 decreases expression ISO obeticholic acid results in decreased expression of FGFR4 mRNA CTD PMID:27939613 NCBI chr17:9,461,541...9,476,268
Ensembl chr17:9,461,547...9,476,242 		JBrowse link
G Fn1 fibronectin 1 decreases expression EXP obeticholic acid decreases expression of fibronectin mRNA in liver in porcine serum induced model of cirrhosis in rat RGD PMID:15980055 RGD:1625201 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression ISO obeticholic acid results in decreased expression of FOS mRNA CTD PMID:27939613 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Foxm1 forkhead box M1 multiple interactions
increases expression		 ISO NR1H4 affects the reaction [obeticholic acid results in increased expression of FOXM1 mRNA]; obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in increased expression of FOXM1 protein] CTD PMID:22135065 PMID:29660435 NCBI chr 4:161,639,538...161,652,012
Ensembl chr 4:161,638,816...161,650,684 		JBrowse link
G Foxp3 forkhead box P3 increases expression ISO obeticholic acid results in increased expression of FOXP3 mRNA CTD PMID:27939613 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase decreases expression ISO obeticholic acid results in decreased expression of GAPDH mRNA CTD PMID:27939613 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO obeticholic acid results in increased expression of GCLM mRNA CTD PMID:26655953 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gfer growth factor, augmenter of liver regeneration multiple interactions ISO [Dietary Fats co-treated with obeticholic acid] results in decreased expression of GFER mRNA; [Dietary Fats co-treated with obeticholic acid] results in decreased expression of GFER protein CTD PMID:35267068 NCBI chr10:13,718,489...13,721,782
Ensembl chr10:13,718,489...13,720,869 		JBrowse link
G Gk glycerol kinase decreases expression ISO obeticholic acid results in decreased expression of GK mRNA CTD PMID:27939613 NCBI chr  X:50,162,089...50,238,707
Ensembl chr  X:50,163,123...50,238,631 		JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial decreases expression ISO obeticholic acid results in decreased expression of GPAM mRNA CTD PMID:27939613 NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639 		JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 decreases expression ISO obeticholic acid results in decreased expression of GPD1 mRNA CTD PMID:27939613 NCBI chr 7:130,842,526...130,851,530
Ensembl chr 7:130,844,138...130,851,529 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO obeticholic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GPT protein]; obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in increased expression of GPT protein]; obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in increased activity of GPT protein]; obeticholic acid promotes the reaction [Dietary Fats results in increased expression of GPT protein] CTD PMID:35267068 PMID:36328986 PMID:36581201 PMID:36787806 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO obeticholic acid results in increased expression of GPX1 mRNA CTD PMID:26655953 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gpx2 glutathione peroxidase 2 decreases expression ISO obeticholic acid results in decreased expression of GPX2 mRNA CTD PMID:27939613 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877 		JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression ISO obeticholic acid results in increased expression of GPX3 mRNA CTD PMID:27939613 NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035 		JBrowse link
G Gsdmd gasdermin D multiple interactions ISO obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in increased cleavage of GSDMD protein] CTD PMID:36328986 NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055 		JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO obeticholic acid results in increased expression of GSR mRNA CTD PMID:26655953 PMID:27939613 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases expression ISO obeticholic acid results in decreased expression of GSTP1 mRNA CTD PMID:27939613 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 increases expression ISO obeticholic acid results in increased expression of GSTT1 mRNA CTD PMID:27939613 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585 		JBrowse link
G Gys2 glycogen synthase 2 increases expression ISO obeticholic acid results in increased expression of GYS2 mRNA CTD PMID:27939613 NCBI chr 4:175,365,054...175,406,228
Ensembl chr 4:175,365,054...175,406,228 		JBrowse link
G Hist2h2be histone cluster 2 H2B family member E decreases expression ISO obeticholic acid results in decreased expression of H2BC11 mRNA CTD PMID:27939613 NCBI chr 2:183,780,583...183,783,030 JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases expression ISO obeticholic acid results in decreased expression of HMGCR mRNA CTD PMID:27939613 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 decreases expression ISO obeticholic acid results in decreased expression of HMGCS1 mRNA CTD PMID:27939613 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha decreases expression
multiple interactions		 EXP
ISO		 obeticholic acid results in decreased expression of HNF4A mRNA
[Dietary Fats co-treated with obeticholic acid] results in decreased expression of HNF4A mRNA; [Dietary Fats co-treated with obeticholic acid] results in decreased expression of HNF4A protein		 CTD PMID:35267068 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320 		JBrowse link
G Hras HRas proto-oncogene, GTPase decreases expression ISO obeticholic acid results in decreased expression of HRAS mRNA CTD PMID:27939613 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 decreases expression ISO obeticholic acid results in decreased expression of HSD17B7 mRNA CTD PMID:27939613 NCBI chr13:82,170,079...82,190,018
Ensembl chr13:82,173,179...82,190,017 		JBrowse link
G Hsd3b7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 decreases expression ISO obeticholic acid results in decreased expression of HSD3B7 mRNA CTD PMID:27939613 NCBI chr 1:182,412,216...182,415,447
Ensembl chr 1:182,412,151...182,415,442 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO obeticholic acid inhibits the reaction [Dietary Fats results in increased expression of HSPA5 protein]; obeticholic acid inhibits the reaction [Palmitic Acid results in increased expression of HSPA5 protein] CTD PMID:26655953 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Hspg2 heparan sulfate proteoglycan 2 decreases expression ISO obeticholic acid results in decreased expression of HSPG2 mRNA CTD PMID:27939613 NCBI chr 5:149,677,437...149,778,594
Ensembl chr 5:149,677,476...149,778,594 		JBrowse link
G Id2 inhibitor of DNA binding 2 decreases expression ISO obeticholic acid results in decreased expression of ID2 mRNA CTD PMID:27939613 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400 		JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 decreases expression ISO obeticholic acid results in decreased expression of IDI1 mRNA CTD PMID:27939613 NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357 		JBrowse link
G Igfals insulin-like growth factor binding protein, acid labile subunit decreases expression ISO obeticholic acid results in decreased expression of IGFALS mRNA CTD PMID:27939613 NCBI chr10:13,897,468...13,903,920
Ensembl chr10:13,898,395...13,902,677 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO obeticholic acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL10 protein]; obeticholic acid inhibits the reaction [Dietary Fats results in increased expression of IL10 protein] CTD PMID:30745416 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il18 interleukin 18 multiple interactions ISO obeticholic acid inhibits the reaction [Methamphetamine results in increased expression of IL18 mRNA] CTD PMID:35688268 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO obeticholic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL1B mRNA]; obeticholic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B mRNA]; obeticholic acid inhibits the reaction [Dietary Fats results in increased expression of IL1B protein]; obeticholic acid inhibits the reaction [Methamphetamine results in increased expression of IL1B mRNA] CTD PMID:27865854 PMID:29660435 PMID:35688268 PMID:38103844 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO obeticholic acid promotes the reaction [Carbon Tetrachloride results in increased expression of IL4 mRNA] CTD PMID:27865854 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO obeticholic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL6 mRNA]; obeticholic acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL6 protein]; obeticholic acid inhibits the reaction [Dietary Fats results in increased expression of IL6 protein]; obeticholic acid inhibits the reaction [Methamphetamine results in increased expression of IL6 mRNA] CTD PMID:29660435 PMID:30745416 PMID:35688268 PMID:36720452 PMID:38103844 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO obeticholic acid results in decreased expression of IL6R mRNA CTD PMID:27939613 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536 		JBrowse link
G Il6st interleukin 6 cytokine family signal transducer decreases expression ISO obeticholic acid results in decreased expression of IL6ST mRNA CTD PMID:27939613 NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936 		JBrowse link
G Inhbb inhibin subunit beta B increases expression ISO obeticholic acid results in increased expression of INHBB mRNA CTD PMID:27939613 NCBI chr13:30,530,860...30,536,566
Ensembl chr13:30,530,860...30,537,832 		JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 decreases expression ISO obeticholic acid results in decreased expression of IRAK1 mRNA CTD PMID:27939613 NCBI chr  X:151,768,621...151,778,521
Ensembl chr  X:151,768,777...151,778,521 		JBrowse link
G Irak2 interleukin-1 receptor-associated kinase 2 decreases expression ISO obeticholic acid results in decreased expression of IRAK2 mRNA CTD PMID:27939613 NCBI chr 4:146,786,004...146,842,615
Ensembl chr 4:146,786,100...146,842,602 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO obeticholic acid results in increased expression of JUN mRNA CTD PMID:27939613 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit decreases expression ISO obeticholic acid results in decreased expression of JUNB mRNA CTD PMID:27939613 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035 		JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP NR0B2 protein affects the reaction [obeticholic acid inhibits the reaction [JUND protein binds to TIMP1 promoter]] CTD PMID:15860571 NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799 		JBrowse link
G Krt18 keratin 18 multiple interactions ISO [Dietary Fats co-treated with obeticholic acid] results in decreased expression of KRT18 mRNA CTD PMID:35267068 NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166 		JBrowse link
G Lbr lamin B receptor decreases expression ISO obeticholic acid results in decreased expression of LBR mRNA CTD PMID:27939613 NCBI chr13:93,539,386...93,564,026
Ensembl chr13:93,538,920...93,564,017 		JBrowse link
G Lcat lecithin cholesterol acyltransferase decreases expression ISO obeticholic acid results in decreased expression of LCAT mRNA CTD PMID:27939613 NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231 		JBrowse link
G Ldlr low density lipoprotein receptor decreases expression ISO obeticholic acid results in decreased expression of LDLR mRNA CTD PMID:27939613 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Leng8 leukocyte receptor cluster member 8 increases expression ISO obeticholic acid results in increased expression of LENG8 mRNA CTD PMID:27939613 NCBI chr 1:70,040,785...70,052,662
Ensembl chr 1:70,040,785...70,052,488 		JBrowse link
G Lgi4 leucine-rich repeat LGI family, member 4 increases expression ISO obeticholic acid results in increased expression of LGI4 mRNA CTD PMID:27939613 NCBI chr 1:86,294,539...86,305,909
Ensembl chr 1:86,295,074...86,304,874 		JBrowse link
G Lime1 Lck interacting transmembrane adaptor 1 decreases expression ISO obeticholic acid results in decreased expression of LIME1 mRNA CTD PMID:27939613 NCBI chr 3:168,490,535...168,496,627
Ensembl chr 3:168,490,074...168,493,127 		JBrowse link
G Lipc lipase C, hepatic type decreases expression ISO obeticholic acid results in decreased expression of LIPC mRNA CTD PMID:27939613 NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464 		JBrowse link
G Lpin1 lipin 1 decreases expression ISO obeticholic acid results in decreased expression of LPIN1 mRNA CTD PMID:27939613 NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097 		JBrowse link
G Lpin2 lipin 2 decreases expression ISO obeticholic acid results in decreased expression of LPIN2 mRNA CTD PMID:27939613 NCBI chr 9:111,083,378...111,158,193
Ensembl chr 9:111,083,745...111,158,193 		JBrowse link
G Lss lanosterol synthase decreases expression ISO obeticholic acid results in decreased expression of LSS mRNA CTD PMID:27939613 NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762 		JBrowse link
G Maf MAF bZIP transcription factor increases expression ISO obeticholic acid results in increased expression of MAF mRNA CTD PMID:27939613 NCBI chr19:43,353,867...43,713,162
Ensembl chr19:43,360,342...43,712,365 		JBrowse link
G Maff MAF bZIP transcription factor F increases expression ISO obeticholic acid results in increased expression of MAFF mRNA CTD PMID:27939613 NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO obeticholic acid inhibits the reaction [Dietary Fats results in decreased expression of MAP1LC3B protein] CTD PMID:26655953 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 decreases expression ISO obeticholic acid results in decreased expression of MAP2K3 mRNA CTD PMID:27939613 NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492 		JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 decreases expression ISO obeticholic acid results in decreased expression of MAP2K6 mRNA CTD PMID:27939613 NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293 		JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 decreases expression ISO obeticholic acid results in decreased expression of MAP2K7 mRNA CTD PMID:27939613 NCBI chr12:2,591,312...2,600,534
Ensembl chr12:2,591,219...2,604,222 		JBrowse link
G Map3k14 mitogen-activated protein kinase kinase kinase 14 decreases expression ISO obeticholic acid results in decreased expression of MAP3K14 mRNA CTD PMID:27939613 NCBI chr10:88,165,349...88,215,558
Ensembl chr10:88,165,351...88,215,523 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 decreases expression ISO obeticholic acid results in decreased expression of MAP3K5 mRNA CTD PMID:27939613 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800 		JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 increases expression ISO obeticholic acid results in increased expression of MAP3K8 mRNA CTD PMID:27939613 NCBI chr17:53,382,908...53,403,216
Ensembl chr17:53,383,131...53,403,216 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO obeticholic acid inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of MAPK1 protein] CTD PMID:27865854 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk11 mitogen-activated protein kinase 11 decreases expression ISO obeticholic acid results in decreased expression of MAPK11 mRNA CTD PMID:27939613 NCBI chr 7:120,218,471...120,225,488
Ensembl chr 7:120,218,478...120,225,395 		JBrowse link
G Mapk12 mitogen-activated protein kinase 12 decreases expression ISO obeticholic acid results in decreased expression of MAPK12 mRNA CTD PMID:27939613 NCBI chr 7:120,206,005...120,216,711
Ensembl chr 7:120,206,271...120,216,664 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO obeticholic acid inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of MAPK3 protein] CTD PMID:27865854 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mdh1 malate dehydrogenase 1 increases expression ISO obeticholic acid results in increased expression of MDH1 mRNA CTD PMID:27939613 NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925 		JBrowse link
G Metrnl meteorin-like, glial cell differentiation regulator decreases expression ISO obeticholic acid results in decreased expression of METRNL mRNA CTD PMID:27939613 NCBI chr10:106,963,880...106,977,875
Ensembl chr10:106,963,880...106,977,869 		JBrowse link
G Mfsd2a MFSD2 lysolipid transporter A, lysophospholipid increases expression ISO obeticholic acid results in increased expression of MFSD2A mRNA CTD PMID:27939613 NCBI chr 5:135,225,801...135,240,744
Ensembl chr 5:135,225,816...135,240,690 		JBrowse link
G Mlkl mixed lineage kinase domain like pseudokinase decreases expression ISO obeticholic acid results in decreased expression of MLKL mRNA CTD PMID:27939613 NCBI chr19:39,277,526...39,304,555
Ensembl chr19:39,276,785...39,304,502 		JBrowse link
G Mllt11 MLLT11, transcription factor 7 cofactor increases expression ISO obeticholic acid results in increased expression of MLLT11 mRNA CTD PMID:27939613 NCBI chr 2:182,795,790...182,804,960
Ensembl chr 2:182,795,790...182,797,199 		JBrowse link
G Mmp2 matrix metallopeptidase 2 increases activity EXP obeticholic acid results in increased activity of MMP2 protein CTD PMID:15860571 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in increased expression of MPO protein] CTD PMID:36328986 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mrtfb myocardin related transcription factor B decreases expression ISO obeticholic acid results in decreased expression of MRTFB mRNA CTD PMID:27939613 NCBI chr10:1,116,315...1,278,106
Ensembl chr10:1,116,310...1,277,897 		JBrowse link
G Msmo1 methylsterol monooxygenase 1 decreases expression ISO obeticholic acid results in decreased expression of MSMO1 mRNA CTD PMID:27939613 NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016 		JBrowse link
G Mvd mevalonate diphosphate decarboxylase decreases expression ISO obeticholic acid results in decreased expression of MVD mRNA CTD PMID:27939613 NCBI chr19:50,496,366...50,506,429
Ensembl chr19:50,496,367...50,507,971 		JBrowse link
G Mvk mevalonate kinase decreases expression ISO obeticholic acid results in decreased expression of MVK mRNA CTD PMID:27939613 NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO obeticholic acid results in decreased expression of MYC mRNA CTD PMID:27939613 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO obeticholic acid inhibits the reaction [Methamphetamine results in increased expression of MYD88 protein] CTD PMID:35688268 PMID:36720452 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression
multiple interactions		 ISO obeticholic acid results in increased expression of NFE2L2 mRNA
[Dietary Fats co-treated with obeticholic acid] results in decreased expression of NFE2L2 protein		 CTD PMID:27939613 PMID:35267068 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression
multiple interactions		 ISO
EXP		 obeticholic acid results in increased expression of NFKB1 mRNA
Obeticholic acid inhibits the reaction [ethanol increases expression of NF-kB protein in liver]		 CTD
RGD		 PMID:27939613 PMID:27939985 RGD:15036816 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 decreases expression ISO obeticholic acid results in decreased expression of NFKB2 mRNA CTD PMID:27939613 NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP Obeticholic acid inhibits the reaction [ethanol decreases expression of Nfkbia protein in liver] RGD PMID:27939985 RGD:15036816 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP Obeticholic acid inhibits the reaction [ethanol increases expression of Nrlp3 protein in liver] RGD PMID:27939985 RGD:15036816 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Npw neuropeptide W decreases expression ISO obeticholic acid results in decreased expression of NPW mRNA CTD PMID:27939613 NCBI chr10:13,680,275...13,681,618
Ensembl chr10:13,680,321...13,681,586 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions
increases expression		 ISO
EXP		 obeticholic acid promotes the reaction [PRMT2 protein binds to NR0B2 promoter]
obeticholic acid results in increased expression of NR0B2 mRNA
obeticholic acid results in increased expression of NR0B2 mRNA; obeticholic acid results in increased expression of NR0B2 protein
NR0B2 protein affects the reaction [obeticholic acid inhibits the reaction [JUND protein binds to TIMP1 promoter]]; NR0B2 protein affects the reaction [obeticholic acid results in decreased expression of and results in decreased secretion of TIMP1 protein]; obeticholic acid inhibits the reaction [Isoniazid results in decreased expression of NR0B2 mRNA]; obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of NR0B2 mRNA]
Obeticholic acid inhibits the reaction [ethanol decreases expression of Nr0b2 protein in liver and intestine]
obeticholic acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NR0B2 protein]; obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in decreased expression of NR0B2 protein]; obeticholic acid inhibits the reaction [Dietary Fats results in decreased expression of NR0B2 mRNA]		 CTD
RGD		 PMID:15644430 PMID:15860571 PMID:15911693 PMID:15980055 PMID:26655953 More... RGD:15036816 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 increases activity
multiple interactions
increases response to substance
increases expression		 ISO
EXP		 obeticholic acid results in increased activity of NR1H4 protein
obeticholic acid binds to and results in increased activity of NR1H4 protein; obeticholic acid promotes the reaction [NR1H4 protein binds to PRMT1 protein]
[obeticholic acid co-treated with 1-Naphthylisothiocyanate] results in increased expression of NR1H4 protein; NR1H4 affects the reaction [obeticholic acid results in increased expression of FOXM1 mRNA]; NR1H4 gene mutant form inhibits the reaction [obeticholic acid inhibits the reaction [TNF results in increased expression of SELP mRNA]]; NR1H4 gene mutant form inhibits the reaction [obeticholic acid results in increased expression of FABP6 mRNA]; NR1H4 gene mutant form inhibits the reaction [obeticholic acid results in increased expression of FGF15 mRNA]; NR1H4 promotes the reaction [obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC2 mRNA]]; obeticholic acid binds to and results in increased activity of NR1H4 protein; obeticholic acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NR1H4 mRNA]; obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in decreased expression of NR1H4 protein]; obeticholic acid inhibits the reaction [Methamphetamine results in increased expression of NR1H4 mRNA]; obeticholic acid inhibits the reaction [Methamphetamine results in increased expression of NR1H4 protein]
NR1H4 protein results in increased susceptibility to obeticholic acid
obeticholic acid binds to and results in increased activity of NR1H4 protein; obeticholic acid inhibits the reaction [Isoniazid results in decreased expression of NR1H4 mRNA]; obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of NR1H4 mRNA]
obeticholic acid results in increased expression of NR1H4 mRNA
obeticholic acid results in increased expression of NR1H4 protein
obeticholic acid increases expression of Nr1H4 mRNA in rat hepatic stellate cells; obeticholic acid increases expression of Nr1h4 mRNA in bile duct ligation and porcine serum induced models of cirrhosis in rat
Obeticholic acid inhibits the reaction [ethanol decreases expression of Nr1h4 mRNA and protein in liver and liver cell nuclei and intestine]		 CTD
RGD		 PMID:15860571 PMID:15911693 PMID:15980055 PMID:17567710 PMID:21242261 More... RGD:1625201, RGD:15036816 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 decreases expression ISO obeticholic acid results in decreased expression of NR5A2 mRNA CTD PMID:27939613 NCBI chr13:48,313,634...48,433,494
Ensembl chr13:48,316,301...48,433,326 		JBrowse link
G Ocln occludin multiple interactions ISO obeticholic acid inhibits the reaction [Methamphetamine results in decreased expression of OCLN protein]; obeticholic acid promotes the reaction [[Dietary Fats co-treated with Dextran Sulfate] results in increased expression of OCLN protein] CTD PMID:35439472 PMID:36720452 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta increases expression ISO obeticholic acid results in increased expression of P4HB mRNA CTD PMID:27939613 NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500 		JBrowse link
G Pc pyruvate carboxylase decreases expression ISO obeticholic acid results in decreased expression of PC mRNA CTD PMID:27939613 NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 decreases expression ISO obeticholic acid results in decreased expression of PCK1 mRNA CTD PMID:27939613 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Pfkfb1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 increases expression ISO obeticholic acid results in increased expression of PFKFB1 mRNA CTD PMID:27939613 NCBI chr  X:19,508,522...19,562,165
Ensembl chr  X:19,508,546...19,562,182 		JBrowse link
G Pgm1 phosphoglucomutase 1 decreases expression ISO obeticholic acid results in decreased expression of PGM1 mRNA CTD PMID:27939613 NCBI chr 5:114,595,298...114,654,728
Ensembl chr 5:114,595,293...114,654,728 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta decreases expression ISO obeticholic acid results in decreased expression of PIK3CD mRNA CTD PMID:27939613 NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 decreases expression ISO obeticholic acid results in decreased expression of PIK3R1 mRNA CTD PMID:27939613 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Pltp phospholipid transfer protein decreases expression ISO obeticholic acid results in decreased expression of PLTP mRNA CTD PMID:27939613 NCBI chr 3:153,574,825...153,592,647
Ensembl chr 3:153,574,825...153,592,647 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
increases expression		 ISO
EXP		 Palmitic Acid inhibits the reaction [obeticholic acid results in increased expression of PPARA mRNA]
obeticholic acid results in increased expression of PPARA mRNA; obeticholic acid results in increased expression of PPARA protein
obeticholic acid inhibits the reaction [Ethanol results in decreased expression of PPARA protein]
Obeticholic acid inhibits the reaction [ethanol decreases expression of Ppara mRNA and protein in liver]		 CTD
RGD		 PMID:15980055 PMID:26655953 PMID:27939985 PMID:27939985 RGD:15036816 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression EXP obeticholic acid results in increased expression of PPARG mRNA; obeticholic acid results in increased expression of PPARG protein CTD PMID:15980055 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppp1r3c protein phosphatase 1, regulatory subunit 3C decreases expression ISO obeticholic acid results in decreased expression of PPP1R3C mRNA CTD PMID:27939613 NCBI chr 1:234,460,958...234,465,961
Ensembl chr 1:234,460,652...234,465,961 		JBrowse link
G Ppp2cb protein phosphatase 2 catalytic subunit beta increases expression ISO obeticholic acid results in increased expression of PPP2CB mRNA CTD PMID:27939613 NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576 		JBrowse link
G Ppp2r1b protein phosphatase 2 scaffold subunit A beta increases expression ISO obeticholic acid results in increased expression of PPP2R1B mRNA CTD PMID:27939613 NCBI chr 8:51,195,860...51,228,442
Ensembl chr 8:51,186,717...51,228,485 		JBrowse link
G Prdx1 peroxiredoxin 1 decreases expression ISO obeticholic acid results in decreased expression of PRDX1 mRNA CTD PMID:27939613 NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856 		JBrowse link
G Prdx6 peroxiredoxin 6 decreases expression ISO obeticholic acid results in decreased expression of PRDX6 mRNA CTD PMID:27939613 NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355 		JBrowse link
G Prkca protein kinase C, alpha increases expression ISO obeticholic acid results in increased expression of PRKCA mRNA CTD PMID:27939613 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Prkce protein kinase C, epsilon increases expression ISO obeticholic acid results in increased expression of PRKCE mRNA CTD PMID:27939613 NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719 		JBrowse link
G Prmt1 protein arginine methyltransferase 1 multiple interactions
increases activity		 ISO obeticholic acid promotes the reaction [NR1H4 protein binds to PRMT1 protein]; obeticholic acid promotes the reaction [PRMT1 protein binds to ABCB11 promoter]
obeticholic acid results in increased activity of PRMT1 protein		 CTD PMID:15911693 NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345 		JBrowse link
G Prmt2 protein arginine methyltransferase 2 multiple interactions ISO obeticholic acid promotes the reaction [PRMT2 protein binds to NR0B2 promoter] CTD PMID:15911693 NCBI chr20:12,394,748...12,420,643
Ensembl chr20:12,394,798...12,420,643 		JBrowse link
G Ptbp2 polypyrimidine tract binding protein 2 decreases expression ISO obeticholic acid results in decreased expression of PTBP2 mRNA CTD PMID:27939613 NCBI chr 2:207,812,659...207,874,019
Ensembl chr 2:207,812,920...207,873,506 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO obeticholic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of RELA protein]; obeticholic acid inhibits the reaction [Methamphetamine results in increased expression of and results in increased phosphorylation of RELA protein]; obeticholic acid inhibits the reaction [Methamphetamine results in increased expression of RELA protein] CTD PMID:29660435 PMID:35688268 PMID:36720452 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ros1 ROS proto-oncogene 1 , receptor tyrosine kinase increases expression ISO obeticholic acid results in increased expression of ROS1 mRNA CTD PMID:27939613 NCBI chr20:31,432,636...31,583,998
Ensembl chr20:31,432,637...31,583,865 		JBrowse link
G Rps6ka2 ribosomal protein S6 kinase A2 increases expression ISO obeticholic acid results in increased expression of RPS6KA2 mRNA CTD PMID:27939613 NCBI chr 1:52,631,582...52,906,739
Ensembl chr 1:52,631,736...52,906,739 		JBrowse link
G Rps6ka4 ribosomal protein S6 kinase A4 decreases expression ISO obeticholic acid results in decreased expression of RPS6KA4 mRNA CTD PMID:27939613 NCBI chr 1:204,021,805...204,032,781
Ensembl chr 1:204,021,806...204,032,761 		JBrowse link
G Rps6ka5 ribosomal protein S6 kinase A5 decreases expression ISO obeticholic acid results in decreased expression of RPS6KA5 mRNA CTD PMID:27939613 NCBI chr 6:119,828,823...120,006,190
Ensembl chr 6:119,828,846...120,006,224 		JBrowse link
G Rras2 RAS related 2 increases expression ISO obeticholic acid results in increased expression of RRAS2 mRNA CTD PMID:27939613 NCBI chr 1:168,233,693...168,303,111
Ensembl chr 1:168,233,693...168,303,111 		JBrowse link
G Rtp3 receptor (chemosensory) transporter protein 3 increases expression ISO obeticholic acid results in increased expression of RTP3 mRNA CTD PMID:27939613 NCBI chr 8:110,970,154...110,975,000
Ensembl chr 8:110,970,160...110,974,699 		JBrowse link
G Rxra retinoid X receptor alpha decreases expression ISO obeticholic acid results in decreased expression of RXRA mRNA CTD PMID:27939613 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712 		JBrowse link
G S100a3 S100 calcium binding protein A3 decreases expression ISO obeticholic acid results in decreased expression of S100A3 mRNA CTD PMID:27939613 NCBI chr 2:176,034,283...176,089,702
Ensembl chr 2:176,049,520...176,089,702 		JBrowse link
G Sc5d sterol-C5-desaturase decreases expression ISO obeticholic acid results in decreased expression of SC5D mRNA CTD PMID:27939613 NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 increases expression ISO obeticholic acid results in increased expression of SCARB1 mRNA CTD PMID:27939613 NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647 		JBrowse link
G Sdc1 syndecan 1 increases expression ISO obeticholic acid results in increased expression of SDC1 mRNA CTD PMID:27939613 NCBI chr 6:31,562,799...31,585,267
Ensembl chr 6:31,562,739...31,585,264 		JBrowse link
G Sdha succinate dehydrogenase complex flavoprotein subunit A multiple interactions ISO obeticholic acid inhibits the reaction [Dietary Fats results in decreased expression of SDHA protein] CTD PMID:26655953 NCBI chr 1:28,935,965...28,960,936
Ensembl chr 1:28,940,164...28,961,535 		JBrowse link
G Selp selectin P multiple interactions ISO NR1H4 gene mutant form inhibits the reaction [obeticholic acid inhibits the reaction [TNF results in increased expression of SELP mRNA]]; obeticholic acid inhibits the reaction [TNF results in increased expression of SELP mRNA] CTD PMID:22135065 NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845 		JBrowse link
G Serpina1 serpin family A member 1 decreases expression ISO obeticholic acid results in decreased expression of SERPINA1 mRNA CTD PMID:27939613 NCBI chr 6:122,866,314...122,888,339
Ensembl chr 6:122,866,312...122,888,339 		JBrowse link
G Serpine1 serpin family E member 1 decreases expression ISO obeticholic acid results in decreased expression of SERPINE1 mRNA CTD PMID:27939613 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Sfn stratifin decreases expression ISO obeticholic acid results in decreased expression of SFN mRNA CTD PMID:27939613 NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314 		JBrowse link
G Sigirr single Ig and TIR domain containing decreases expression ISO obeticholic acid results in decreased expression of SIGIRR mRNA CTD PMID:27939613 NCBI chr 1:196,195,363...196,208,692
Ensembl chr 1:196,199,462...196,202,269 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression
multiple interactions		 ISO
EXP		 obeticholic acid results in decreased expression of SLC10A1 mRNA
[1-Naphthylisothiocyanate co-treated with obeticholic acid] results in decreased expression of SLC10A1 protein; obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in decreased expression of SLC10A1 mRNA]; obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA]; obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 protein]
Obeticholic acid inhibits the reaction [ethanol decreases expression of Slc10a1 protein in liver]
obeticholic acid promotes the reaction [Isoniazid results in decreased expression of SLC10A1 mRNA]		 CTD
RGD		 PMID:15644430 PMID:15911693 PMID:29660435 PMID:32673658 PMID:36328986 More... RGD:15036816 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670 		JBrowse link
G Slc13a5 solute carrier family 13 member 5 decreases expression ISO obeticholic acid results in decreased expression of SLC13A5 mRNA CTD PMID:27939613 NCBI chr10:56,866,249...56,891,189
Ensembl chr10:56,866,249...56,890,945 		JBrowse link
G Slc25a1 solute carrier family 25 member 1 decreases expression ISO obeticholic acid results in decreased expression of SLC25A1 mRNA CTD PMID:27939613 NCBI chr11:83,055,764...83,058,781
Ensembl chr11:83,055,748...83,058,781 		JBrowse link
G Slc25a10 solute carrier family 25 member 10 decreases expression ISO obeticholic acid results in decreased expression of SLC25A10 mRNA CTD PMID:27939613 NCBI chr10:105,765,598...105,775,159
Ensembl chr10:105,765,372...105,773,556 		JBrowse link
G Slc25a12 solute carrier family 25 member 12 decreases expression ISO obeticholic acid results in decreased expression of SLC25A12 mRNA CTD PMID:27939613 NCBI chr 3:56,097,166...56,191,841
Ensembl chr 3:56,097,269...56,192,100 		JBrowse link
G Slc27a5 solute carrier family 27 member 5 decreases expression ISO obeticholic acid results in decreased expression of SLC27A5 mRNA CTD PMID:27939613 NCBI chr 1:73,616,556...73,627,149
Ensembl chr 1:73,616,564...73,627,172 		JBrowse link
G Slc51a solute carrier family 51 member A increases expression ISO obeticholic acid results in increased expression of SLC51A mRNA; obeticholic acid results in increased expression of SLC51A protein CTD PMID:26655953 PMID:27939613 NCBI chr11:68,299,086...68,313,485
Ensembl chr11:68,299,086...68,313,485 		JBrowse link
G Slc51b SLC51 subunit beta increases expression
multiple interactions		 ISO
EXP		 obeticholic acid results in increased expression of SLC51B mRNA
obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of SLC51B mRNA]		 CTD PMID:26655953 PMID:27255380 PMID:27939613 NCBI chr 8:65,931,891...65,939,953
Ensembl chr 8:65,931,890...65,940,145 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions
increases expression		 EXP
ISO		 obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of SLCO1B2 mRNA]
obeticholic acid results in increased expression of SLCO1B2 mRNA
obeticholic acid results in increased expression of SLCO1B3 mRNA		 CTD PMID:27255380 PMID:27939613 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
G Socs2 suppressor of cytokine signaling 2 decreases expression ISO obeticholic acid results in decreased expression of SOCS2 mRNA CTD PMID:27939613 NCBI chr 7:30,006,360...30,045,161
Ensembl chr 7:30,008,578...30,043,548 		JBrowse link
G Sod2 superoxide dismutase 2 decreases expression ISO obeticholic acid results in decreased expression of SOD2 mRNA CTD PMID:27939613 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO obeticholic acid inhibits the reaction [Dietary Fats results in decreased expression of SQSTM1 protein] CTD PMID:26655953 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
decreases expression		 ISO
EXP		 obeticholic acid inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]
obeticholic acid results in decreased expression of SREBF1 mRNA
Obeticholic acid inhibits the reaction [ethanol increases expression of Srebf1 mRNA and protein in liver]		 CTD
RGD		 PMID:27939613 PMID:27939985 PMID:27939985 RGD:15036816 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions
decreases expression		 ISO obeticholic acid inhibits the reaction [Dietary Fats results in increased expression of SREBF2 mRNA]
obeticholic acid results in decreased expression of SREBF2 mRNA		 CTD PMID:26655953 PMID:27939613 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 multiple interactions ISO obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in increased expression of SULT2A1 mRNA] CTD PMID:29660435 NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134 		JBrowse link
G Szrd1 SUZ RNA binding domain containing 1 increases expression ISO obeticholic acid results in increased expression of SZRD1 mRNA CTD PMID:27939613 NCBI chr 5:153,418,748...153,443,286
Ensembl chr 5:153,418,748...153,443,252 		JBrowse link
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 decreases expression ISO obeticholic acid results in decreased expression of TAB1 mRNA CTD PMID:27939613 NCBI chr 7:111,675,829...111,707,058
Ensembl chr 7:111,686,371...111,707,058 		JBrowse link
G Tapbp TAP binding protein decreases expression ISO obeticholic acid results in decreased expression of TAPBP mRNA CTD PMID:27939613 NCBI chr20:4,956,937...4,966,191
Ensembl chr20:4,956,937...4,966,181 		JBrowse link
G Tcea2 transcription elongation factor A2 increases expression ISO obeticholic acid results in increased expression of TCEA2 mRNA CTD PMID:27939613 NCBI chr 3:168,796,244...168,804,125
Ensembl chr 3:168,796,331...168,804,116 		JBrowse link
G Tecr trans-2,3-enoyl-CoA reductase decreases expression ISO obeticholic acid results in decreased expression of TECR mRNA CTD PMID:27939613 NCBI chr19:24,526,700...24,568,168
Ensembl chr19:24,541,615...24,568,168 		JBrowse link
G Tedc1 tubulin epsilon and delta complex 1 decreases expression ISO obeticholic acid results in decreased expression of TEDC1 mRNA CTD PMID:27939613 NCBI chr 6:132,234,764...132,245,164
Ensembl chr 6:132,236,925...132,244,928 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression		 EXP
ISO		 obeticholic acid inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]
obeticholic acid results in decreased expression of TGFB1 mRNA
obeticholic acid inhibits the reaction [[Dietary Fats co-treated with Dextran Sulfate] results in increased expression of TGFB1 protein]		 CTD PMID:15980055 PMID:27939613 PMID:35439472 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 decreases expression ISO obeticholic acid results in decreased expression of TGFB2 mRNA CTD PMID:27939613 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Tgfb3 transforming growth factor, beta 3 increases expression ISO obeticholic acid results in increased expression of TGFB3 mRNA CTD PMID:27939613 NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 decreases expression ISO obeticholic acid results in decreased expression of TGFBR1 mRNA CTD PMID:27939613 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions
decreases expression		 EXP
ISO		 NR0B2 protein affects the reaction [obeticholic acid inhibits the reaction [JUND protein binds to TIMP1 promoter]]; NR0B2 protein affects the reaction [obeticholic acid results in decreased expression of and results in decreased secretion of TIMP1 protein]; obeticholic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 mRNA]; obeticholic acid results in decreased expression of and results in decreased secretion of TIMP1 protein
obeticholic acid results in decreased expression of TIMP1 mRNA		 CTD PMID:15860571 PMID:27939613 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions EXP obeticholic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP2 mRNA] CTD PMID:15860571 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO obeticholic acid promotes the reaction [[Dietary Fats co-treated with Dextran Sulfate] results in increased expression of TJP1 protein] CTD PMID:35439472 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tk1 thymidine kinase 1 decreases expression ISO obeticholic acid results in decreased expression of TK1 mRNA CTD PMID:27939613 NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO obeticholic acid inhibits the reaction [[Dietary Fats co-treated with Dextran Sulfate] results in increased expression of TLR4 protein]; obeticholic acid inhibits the reaction [Methamphetamine results in increased expression of TLR4 protein] CTD PMID:35439472 PMID:35688268 PMID:36720452 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases secretion		 ISO
EXP		 NR1H4 gene mutant form inhibits the reaction [obeticholic acid inhibits the reaction [TNF results in increased expression of SELP mRNA]]; obeticholic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TNF mRNA]; obeticholic acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; obeticholic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; obeticholic acid inhibits the reaction [Dietary Fats results in increased expression of TNF protein]; obeticholic acid inhibits the reaction [Methamphetamine results in increased expression of TNF mRNA]; obeticholic acid inhibits the reaction [TNF results in increased expression of SELP mRNA]
obeticholic acid inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
obeticholic acid results in decreased secretion of TNF protein
Obeticholic acid inhibits the reaction [ethanol increases expression of Tnf protein in liver]		 CTD
RGD		 PMID:21242261 PMID:22135065 PMID:27865854 PMID:29660435 PMID:30745416 More... RGD:15036816 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B increases expression ISO obeticholic acid results in increased expression of TNFRSF1B mRNA CTD PMID:27939613 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206 		JBrowse link
G Traf2 Tnf receptor-associated factor 2 decreases expression ISO obeticholic acid results in decreased expression of TRAF2 mRNA CTD PMID:27939613 NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538 		JBrowse link
G Txn1 thioredoxin 1 decreases expression ISO obeticholic acid results in decreased expression of TXN mRNA CTD PMID:27939613 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629 		JBrowse link
G Txnrd2 thioredoxin reductase 2 decreases expression ISO obeticholic acid results in decreased expression of TXNRD2 mRNA CTD PMID:27939613 NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156 		JBrowse link
G Tyk2 tyrosine kinase 2 decreases expression ISO obeticholic acid results in decreased expression of TYK2 mRNA CTD PMID:27939613 NCBI chr 8:19,641,881...19,667,157
Ensembl chr 8:19,641,884...19,667,044 		JBrowse link
G Tymp thymidine phosphorylase decreases expression ISO obeticholic acid results in decreased expression of TYMP mRNA CTD PMID:27939613 NCBI chr 7:120,438,768...120,444,088
Ensembl chr 7:120,438,770...120,443,874
Ensembl chr 7:120,438,770...120,443,874 		JBrowse link
G Ube2e3 ubiquitin-conjugating enzyme E2E 3 increases expression ISO obeticholic acid results in increased expression of UBE2E3 mRNA CTD PMID:27939613 NCBI chr 3:63,786,976...63,851,400
Ensembl chr 3:63,786,650...63,843,237 		JBrowse link
G Ubxn10 UBX domain protein 10 increases expression ISO obeticholic acid results in increased expression of UBXN10 mRNA CTD PMID:27939613 NCBI chr 5:150,953,772...150,959,608
Ensembl chr 5:150,950,731...150,959,744 		JBrowse link
G Uckl1 uridine-cytidine kinase 1-like 1 decreases expression ISO obeticholic acid results in decreased expression of UCKL1 mRNA CTD PMID:27939613 NCBI chr 3:168,674,849...168,687,513
Ensembl chr 3:168,674,849...168,698,091 		JBrowse link
G Ugp2 UDP-glucose pyrophosphorylase 2 increases expression ISO obeticholic acid results in increased expression of UGP2 mRNA CTD PMID:27939613 NCBI chr14:95,456,330...95,497,483
Ensembl chr14:95,456,330...95,496,830 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression
increases glucuronidation		 ISO obeticholic acid results in increased expression of UGT1A1 mRNA
UGT1A1 protein results in increased glucuronidation of obeticholic acid		 CTD PMID:27939613 PMID:31299240 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation
multiple interactions		 ISO UGT1A3 protein results in increased glucuronidation of obeticholic acid
[Lapatinib results in decreased activity of UGT1A3 protein] which results in decreased glucuronidation of obeticholic acid		 CTD PMID:31299240 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 decreases expression
increases glucuronidation		 ISO obeticholic acid results in decreased expression of UGT1A4 mRNA
UGT1A4 protein results in increased glucuronidation of obeticholic acid		 CTD PMID:27939613 PMID:31299240 NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 decreases expression ISO obeticholic acid results in decreased expression of UGT1A6 mRNA CTD PMID:27939613 NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 decreases expression ISO obeticholic acid results in decreased expression of UGT1A9 mRNA CTD PMID:27939613 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 decreases expression ISO obeticholic acid results in decreased expression of UGT2B7 mRNA CTD PMID:27939613 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
G Upb1 beta-ureidopropionase 1 decreases expression ISO obeticholic acid results in decreased expression of UPB1 mRNA CTD PMID:27939613 NCBI chr20:13,217,252...13,243,590
Ensembl chr20:13,217,258...13,243,590 		JBrowse link
G Upp1 uridine phosphorylase 1 increases expression ISO obeticholic acid results in increased expression of UPP1 mRNA CTD PMID:27939613 NCBI chr14:83,809,495...83,829,299
Ensembl chr14:83,809,960...83,829,462 		JBrowse link
G Upp2 uridine phosphorylase 2 increases expression ISO obeticholic acid results in increased expression of UPP2 mRNA CTD PMID:27939613 NCBI chr 3:43,273,048...43,317,417
Ensembl chr 3:43,273,048...43,317,417 		JBrowse link
G Uroc1 urocanate hydratase 1 increases expression ISO obeticholic acid results in increased expression of UROC1 mRNA CTD PMID:27939613 NCBI chr 4:122,844,933...122,876,584
Ensembl chr 4:122,844,926...122,876,591 		JBrowse link
G Xdh xanthine dehydrogenase increases expression ISO obeticholic acid results in increased expression of XDH mRNA CTD PMID:27939613 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      biological role 19785
        pharmacological role 19030
          agonist 18607
            farnesoid X receptor agonist 290
              obeticholic acid 290
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            organic molecule 19658
                              organic cyclic compound 19471
                                organic polycyclic compound 17244
                                  steroid 14672
                                    steroid fundamental parent 14483
                                      cholane 999
                                        cholanoid 1001
                                          cholanic acids 983
                                            cholanic acid 985
                                              5beta-cholanic acid 983
                                                hydroxy-5beta-cholanic acid 985
                                                  dihydroxy-5beta-cholanic acid 833
                                                    chenodeoxycholic acid 525
                                                      obeticholic acid 290
paths to the root