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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 67377
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hsd3b2
Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
Acc ID: CHEBI:47519
Term: ketoconazole
Definition: A racemate consisting of equimolar amounts of (2R,4S)- and (2S,4R)-ketoconazole.
Chemical ID: MESH:D007654
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hsd3b2decreases expressionISOHSD3B2 (Homo sapiens)6480464CTDKetoconazole results in decreased expression of HSD3B2 mRNAPMID:16935330
Hsd3b2multiple interactionsISOHSD3B2 (Homo sapiens)6480464CTD[Colforsin co-treated with Ketoconazole] results in decreased expression of HSD3B2 mRNAPMID:16935330
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