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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 632286
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc22a8
Name: solute carrier family 22 member 8
Acc ID: CHEBI:15551
Term: prostaglandin E2
Definition: Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.
Chemical ID: MESH:D015232
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc22a8decreases expressionEXP 6480464CTDDinoprostone results in decreased expression of SLC22A8 proteinPMID:19605544
Slc22a8affects transportISOSLC22A8 (Homo sapiens)6480464CTDSLC22A8 protein affects the transport of DinoprostonePMID:11306713
Slc22a8increases transportISOSlc22a8 (Mus musculus)6480464CTDSLC22A8 protein results in increased transport of DinoprostonePMID:15100168
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