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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631424
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Itgal
Name: integrin subunit alpha L
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Itgalincreases expressionISOItgal (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of ITGAL mRNA; Lipopolysaccharides results in increased expression of ITGAL proteinPMID:10198263
Itgalmultiple interactionsISOItgal (Mus musculus)6480464CTDStaurosporine inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAL mRNA]; Staurosporine inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAL protein]PMID:10198263
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