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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631423
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tp53inp1
Name: tumor protein p53 inducible nuclear protein 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tp53inp1decreases methylationISOTP53INP1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of TP53INP1 5' UTR; Benzo(a)pyrene results in decreased methylation of TP53INP1 promoterPMID:27901495
Tp53inp1increases expressionISOTrp53inp1 (Mus musculus)6480464CTDBenzo(a)pyrene metabolite results in increased expression of TRP53INP1 mRNA; Benzo(a)pyrene results in increased expression of TRP53INP1 mRNAPMID:21569818 PMID:22228805 PMID:22610609 PMID:23735875 PMID:25908611 PMID:32553695
Tp53inp1increases expressionISOTP53INP1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of TP53INP1 mRNAPMID:20106945 PMID:21632981 PMID:22316170 PMID:26238291
Tp53inp1multiple interactionsISOTrp53inp1 (Mus musculus)6480464CTD[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of TRP53INP1 mRNAPMID:27858113
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