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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631344
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abca1
Name: ATP binding cassette subfamily A member 1
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abca1decreases expressionEXP 6480464CTDNicotine results in decreased expression of ABCA1 mRNA; Nicotine results in decreased expression of ABCA1 proteinPMID:30036686
Abca1decreases expressionISOABCA1 (Homo sapiens)6480464CTDNicotine results in decreased expression of ABCA1 mRNA; Nicotine results in decreased expression of ABCA1 proteinPMID:30036686
Abca1multiple interactionsISOABCA1 (Homo sapiens)6480464CTDGW 3965 inhibits the reaction [Nicotine results in decreased expression of ABCA1 mRNA]; GW 3965 inhibits the reaction [Nicotine results in decreased expression of ABCA1 protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCA1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCA1 protein]PMID:30036686
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