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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628868
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Itgb3
Name: integrin subunit beta 3
Acc ID: CHEBI:139030
Term: hydroxysafflor yellow A
Definition: A C-glycosyl compound that is 3,4,5-trihydroxycyclohexa-2,5-dien-1-one which is substituted by beta-D-glucosyl groups at positions 2 and 4, and by a p-hydroxycinnamoyl group at position 6. It is the main bioactive compound of a traditional Chinese medicine obtained from safflower (Carthamus tinctorius).
Chemical ID: MESH:C085278
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Itgb3multiple interactionsEXP 6480464CTDhydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Particulate Matter results in increased expression of ITGB3 protein]]; hydroxysafflor yellow A inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [Vehicle Emissions results in increased expression of ITGB3 protein]]; hydroxysafflor yellow A inhibits the reaction [Particulate Matter results in increased expression of ITGB3 protein]; hydroxysafflor yellow A inhibits the reaction [Vehicle Emissions results in increased expression of ITGB3 protein]PMID:24192212
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