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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628774
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2l11
Name: Bcl2-like 11
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2l11affects expressionISOBCL2L11 (Homo sapiens)6480464CTDArsenic Trioxide affects the expression of BCL2L11 proteinPMID:36509116
Bcl2l11increases degradationISOBCL2L11 (Homo sapiens)6480464CTDArsenic Trioxide results in increased degradation of BCL2L11 proteinPMID:36509116
Bcl2l11increases expressionISOBCL2L11 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of BCL2L11 mRNA; Arsenic Trioxide results in increased expression of BCL2L11 proteinPMID:17203211 PMID:17530438 PMID:21655183 PMID:23700110 PMID:24956101 PMID:27430728 PMID:29574283
Bcl2l11multiple interactionsISOBCL2L11 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Arsenic Trioxide results in increased degradation of BCL2L11 protein]; [Arsenic Trioxide co-treated with Curcumin] results in increased expression of BCL2L11 protein; [Arsenic Trioxide co-treated with VS-5584] results in increased expression of BCL2L11 mRNA; [Arsenic Trioxide results in increased expression of BCL2L11 protein] which results in decreased phosphorylation of AKT1 protein; Arsenic Trioxide inhibits the reaction [BCL2L11 protein binds to MCL1 protein]; Arsenic Trioxide inhibits the reaction [Tunicamycin results in increased expression of BCL2L11 protein]; Arsenic Trioxide promotes the reaction [Matrines results in increased expression of BCL2L11 protein]; BCL2L11 mutant form inhibits the reaction [Arsenic Trioxide results in increased cleavage of CASP3 protein]; BCL2L11 mutant form inhibits the reaction [Arsenic Trioxide results in increased cleavage of CASP9 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Arsenic Trioxide results in increased degradation of BCL2L11 protein]; Bortezomib inhibits the reaction [Arsenic Trioxide results in increased degradation of BCL2L11 protein]; Matrines promotes the reaction [Arsenic Trioxide results in increased expression of BCL2L11 protein]; MMP9 protein inhibits the reaction [Arsenic Trioxide inhibits the reaction [BCL2L11 protein binds to MCL1 protein]]; MMP9 protein inhibits the reaction [Arsenic Trioxide results in increased expression of BCL2L11 protein]PMID:21655183 PMID:23700110 PMID:24956101 PMID:27430728 PMID:29574283 PMID:36509116
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