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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628618
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adgrg2
Name: adhesion G protein-coupled receptor G2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adgrg2affects methylationISOADGRG2 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of ADGRG2 5' UTR; Benzo(a)pyrene affects the methylation of ADGRG2 intron; Benzo(a)pyrene affects the methylation of ADGRG2 promoterPMID:27901495 PMID:30157460
Adgrg2decreases expressionISOADGRG2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of ADGRG2 mRNAPMID:17879257
Adgrg2increases expressionISOADGRG2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of ADGRG2 mRNAPMID:20064835 PMID:32234424
Adgrg2increases expressionISOAdgrg2 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of ADGRG2 mRNAPMID:23735875
Adgrg2increases methylationISOADGRG2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of ADGRG2 3' UTRPMID:27901495
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