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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628615
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lgr4
Name: leucine-rich repeat-containing G protein-coupled receptor 4
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lgr4decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of LGR4 mRNAPMID:25181051 PMID:32145629
Lgr4increases expressionEXP 6480464CTDbisphenol A results in increased expression of LGR4 mRNAPMID:29097150 PMID:30816183
Lgr4multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Estradiol] results in increased expression of LGR4 mRNAPMID:26496021
Lgr4affects expressionISOLGR4 (Homo sapiens)6480464CTDbisphenol A affects the expression of LGR4 mRNAPMID:30903817
Lgr4decreases expressionISOLGR4 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of LGR4 mRNAPMID:23146750
Lgr4decreases methylationISOLgr4 (Mus musculus)6480464CTDbisphenol A results in decreased methylation of LGR4 promoterPMID:27312807
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