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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621867
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccn5
Name: cellular communication network factor 5
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccn5decreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of CCN5 mRNAPMID:21839799
Ccn5affects methylationISOCCN5 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of WISP2 promoterPMID:27901495
Ccn5decreases expressionISOCcn5 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of CCN5 mRNAPMID:15034205 PMID:21569818
Ccn5increases expressionISOCcn5 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of CCN5 mRNAPMID:22228805
Ccn5multiple interactionsISOCcn5 (Mus musculus)6480464CTDAHR protein promotes the reaction [Benzo(a)pyrene results in decreased expression of CCN5 mRNA]; Benzo(a)pyrene promotes the reaction [AHR protein binds to CCN5 promoter]PMID:15034205 PMID:19654925
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