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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621759
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vwf
Name: von Willebrand factor
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vwfdecreases expressionISOVWF (Homo sapiens)6480464CTDDoxorubicin results in decreased expression of VWF mRNAPMID:29803840
Vwfincreases expressionISOVwf (Mus musculus)6480464CTDDoxorubicin results in increased expression of VWF proteinPMID:30517846
Vwfmultiple interactionsISOVwf (Mus musculus)6480464CTD[Dexrazoxane co-treated with Doxorubicin] results in increased expression of VWF protein; Dexrazoxane inhibits the reaction [Doxorubicin results in increased expression of VWF protein]PMID:30517846
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