Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	621747
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Gsr
Name:	glutathione-disulfide reductase

Acc ID:	CHEBI:9288
Term:	streptozocin
Definition:	An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID:	MESH:D013311

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Gsr	affects activity	EXP		6480464	CTD	Streptozocin affects the activity of GSR protein	PMID:24752916
Gsr	decreases activity	EXP		6480464	CTD	Streptozocin results in decreased activity of GSR protein	PMID:17145126 PMID:19682444 PMID:19840221 PMID:20053369 PMID:20620209 PMID:22476978 PMID:23122718 PMID:26748309 PMID:30817903 PMID:31009641 PMID:32864810 PMID:35414346 PMID:37354076
Gsr	decreases expression	EXP		6480464	CTD	Streptozocin results in decreased expression of GSR protein	PMID:33724628
Gsr	increases activity	EXP		6480464	CTD	Streptozocin results in increased activity of GSR protein	PMID:11424224 PMID:22940631 PMID:32812462 PMID:34039237
Gsr	multiple interactions	EXP		6480464	CTD	[Carmustine results in decreased activity of GSR protein] which results in increased susceptibility to Streptozocin; [Dietary Fats co-treated with Streptozocin] results in decreased activity of GSR protein; [Niacinamide co-treated with Streptozocin] results in decreased activity of GSR protein; [Streptozocin co-treated with Dietary Fats] results in decreased activity of GSR protein; [Streptozocin co-treated with Niacinamide] results in decreased activity of GSR protein; [Zinc Sulfate results in increased abundance of Zinc] inhibits the reaction [Streptozocin results in decreased activity of GSR protein]; Acetylcysteine inhibits the reaction [Streptozocin results in decreased activity of GSR protein]; arjunolic acid inhibits the reaction [Streptozocin results in decreased activity of GSR protein]; Bezafibrate inhibits the reaction [Streptozocin results in decreased activity of GSR protein]; caryophyllene inhibits the reaction [Streptozocin results in decreased activity of GSR protein]; Chromium inhibits the reaction [Streptozocin results in decreased activity of GSR protein]; chromium tripicolinate inhibits the reaction [Streptozocin results in decreased activity of GSR protein]; Ellagic Acid inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased activity of GSR protein]; Gallic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased activity of GSR protein]; geraniol inhibits the reaction [Streptozocin affects the activity of GSR protein]; Gliclazide inhibits the reaction [[Niacinamide co-treated with Streptozocin] results in decreased activity of GSR protein]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of GSR protein]; Glyburide inhibits the reaction [Streptozocin results in decreased activity of GSR protein]; Glyburide inhibits the reaction [Streptozocin results in decreased expression of GSR protein]; INS protein promotes the reaction [Streptozocin results in increased activity of GSR protein]; Metformin inhibits the reaction [Streptozocin results in decreased activity of GSR protein]; morin inhibits the reaction [Streptozocin results in decreased activity of GSR protein]; piperlongumine inhibits the reaction [Streptozocin results in decreased expression of GSR protein]; Resveratrol inhibits the reaction [[Niacinamide co-treated with Streptozocin] results in decreased activity of GSR protein]; Resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of GSR protein]; Rosiglitazone inhibits the reaction [Streptozocin promotes the reaction [Dietary Fats results in decreased activity of GSR protein]]; Sodium Selenite inhibits the reaction [Streptozocin results in decreased activity of GSR protein]; Streptozocin promotes the reaction [Dietary Fats results in decreased activity of GSR protein]; Zinc inhibits the reaction [Streptozocin results in decreased activity of GSR protein]	PMID:15720826 PMID:17145126 PMID:19682444 PMID:19840221 PMID:20053369 PMID:20307516 PMID:21439372 PMID:22476978 PMID:22940631 PMID:23122718 PMID:24752916 PMID:24877639 PMID:26341651 PMID:26748309 PMID:29441829 PMID:31009641 PMID:32864810 PMID:33724628 PMID:35414346

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