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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621747
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsr
Name: glutathione-disulfide reductase
Acc ID: CHEBI:44185
Term: methotrexate
Definition: A pteridine that has formula C20H22N8O5.
Chemical ID: MESH:D008727
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsrdecreases activityEXP 6480464CTDMethotrexate results in decreased activity of GSR proteinPMID:28479099 PMID:33530773
Gsrmultiple interactionsEXP 6480464CTD5,7,3',4'-tetramethylluteolin inhibits the reaction [Methotrexate results in decreased activity of GSR protein]; [Aspartame co-treated with Methotrexate] results in decreased activity of GSR protein; Chlorogenic Acid inhibits the reaction [Methotrexate results in decreased activity of GSR protein]PMID:25009784 PMID:28479099 PMID:33530773
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