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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621675
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Timp1
Name: TIMP metallopeptidase inhibitor 1
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Timp1decreases expressionEXP 6480464CTDStreptozocin results in decreased expression of TIMP1 mRNAPMID:32662907
Timp1increases activityEXP 6480464CTDStreptozocin results in increased activity of TIMP1 proteinPMID:25246140
Timp1increases expressionEXP 6480464CTDStreptozocin results in increased expression of TIMP1 mRNAPMID:18246672
Timp1multiple interactionsEXP 6480464CTD[Resveratrol co-treated with Streptozocin] results in increased expression of TIMP1 mRNA; Olive Oil promotes the reaction [Streptozocin results in increased activity of TIMP1 protein]; rhapontin inhibits the reaction [Streptozocin results in decreased expression of TIMP1 mRNA]PMID:25246140 PMID:25905778 PMID:32662907
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