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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621655
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gucy1a2
Name: guanylate cyclase 1 soluble subunit alpha 2
Acc ID: CHEBI:164200
Term: triclosan
Definition: An aromatic ether that is phenol which is substituted at C-5 by a chloro group and at C-2 by a 2,4-dichlorophenoxy group. It is widely used as a preservative and antimicrobial agent in personal care products such as soaps, skin creams, toothpaste and deodorants as well as in household items such as plastic chopping boards, sports equipment and shoes.
Chemical ID: MESH:D014260
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gucy1a2decreases expressionISOGUCY1A2 (Homo sapiens)6480464CTDTriclosan results in decreased expression of GUCY1A2 mRNAPMID:30510588
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