Gucy1a2 (guanylate cyclase 1 soluble subunit alpha 2) - Rat Genome Database

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Gene: Gucy1a2 (guanylate cyclase 1 soluble subunit alpha 2) Rattus norvegicus
Analyze
Symbol: Gucy1a2
Name: guanylate cyclase 1 soluble subunit alpha 2
RGD ID: 621655
Description: Exhibits guanylate cyclase activity. Predicted to be involved in positive regulation of nitric oxide mediated signal transduction. Predicted to localize to cytosol. Orthologous to human GUCY1A2 (guanylate cyclase 1 soluble subunit alpha 2); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: GCS-alpha-2; guanylate cyclase 1, soluble, alpha 2; guanylate cyclase soluble subunit alpha-2; LOC497842; similar to guanylate cyclase 1, soluble, alpha 2; soluble guanylyl cyclase alpha2 subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28500,212 - 900,201 (+)NCBI
Rnor_6.0 Ensembl8408,001 - 899,974 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.08408,001 - 899,851 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08417,520 - 903,360 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48113,253 - 262,544 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18113,252 - 262,544 (+)NCBI
Celera8386,346 - 771,749 (+)NCBICelera
Cytogenetic Map8q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (TAS)

Molecular Function

References

Additional References at PubMed
PMID:20623   PMID:9925020   PMID:14687925   PMID:16569663   PMID:16614755   PMID:18572161   PMID:19141686   PMID:22608751   PMID:22806360   PMID:23579428  


Genomics

Comparative Map Data
Gucy1a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28500,212 - 900,201 (+)NCBI
Rnor_6.0 Ensembl8408,001 - 899,974 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.08408,001 - 899,851 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08417,520 - 903,360 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48113,253 - 262,544 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18113,252 - 262,544 (+)NCBI
Celera8386,346 - 771,749 (+)NCBICelera
Cytogenetic Map8q11NCBI
GUCY1A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11106,674,019 - 107,018,476 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl11106,674,012 - 107,018,524 (-)EnsemblGRCh38hg38GRCh38
GRCh3811106,674,019 - 107,018,476 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711106,544,745 - 106,889,202 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611106,063,120 - 106,394,381 (-)NCBINCBI36hg18NCBI36
Build 3411106,063,119 - 106,394,381NCBI
Celera11103,723,340 - 104,055,014 (-)NCBI
Cytogenetic Map11q22.3NCBI
HuRef11102,477,634 - 102,824,743 (-)NCBIHuRef
CHM1_111106,428,121 - 106,772,413 (-)NCBICHM1_1
Gucy1a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3993,532,349 - 3,905,791 (+)NCBIGRCm39mm39
GRCm39 Ensembl93,532,778 - 3,894,736 (+)Ensembl
GRCm3893,532,349 - 3,905,791 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl93,532,778 - 3,894,736 (+)EnsemblGRCm38mm10GRCm38
MGSCv3793,532,354 - 3,897,342 (+)NCBIGRCm37mm9NCBIm37
MGSCv3693,532,778 - 3,905,782 (+)NCBImm8
Celera3118,798,542 - 119,162,647 (-)NCBICelera
Cytogenetic Map9A1NCBI
Gucy1a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554129,225,305 - 9,480,206 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554129,218,029 - 9,480,333 (-)NCBIChiLan1.0ChiLan1.0
GUCY1A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111105,060,684 - 105,394,346 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v011101,565,279 - 101,910,136 (-)NCBIMhudiblu_PPA_v0panPan3
GUCY1A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1525,291,019 - 25,718,918 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl525,291,583 - 25,686,947 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha525,216,400 - 25,557,679 (+)NCBI
ROS_Cfam_1.0525,315,662 - 25,746,950 (+)NCBI
UMICH_Zoey_3.1525,369,411 - 25,798,051 (+)NCBI
UNSW_CanFamBas_1.0525,255,743 - 25,598,578 (+)NCBI
UU_Cfam_GSD_1.0525,321,581 - 25,750,065 (+)NCBI
Gucy1a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494789,719,092 - 89,961,167 (-)NCBI
SpeTri2.0NW_0049365511,573,930 - 1,814,685 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GUCY1A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl962,101,613 - 62,499,581 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1962,101,581 - 62,510,803 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2968,952,382 - 69,391,579 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GUCY1A2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1198,108,081 - 98,439,453 (-)NCBI
Gucy1a2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247841,449,275 - 1,796,331 (-)NCBI

Position Markers
RH127087  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21465,683,640 - 65,683,847 (+)MAPPER
mRatBN7.28819,421 - 819,628 (+)MAPPER
Rnor_6.08833,086 - 833,292NCBIRnor6.0
Rnor_6.01470,178,072 - 70,178,278NCBIRnor6.0
Rnor_5.01470,221,256 - 70,221,462UniSTSRnor5.0
Rnor_5.08836,484 - 836,690UniSTSRnor5.0
RGSC_v3.41470,755,388 - 70,755,594UniSTSRGSC3.4
RGSC_v3.48190,903 - 191,109UniSTSRGSC3.4
Celera8704,176 - 704,382UniSTS
Celera1464,664,740 - 64,664,946UniSTS
Cytogenetic Map8q11UniSTS
Cytogenetic Map14q21UniSTS
AU048567  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera8469,870 - 469,989UniSTS
Cytogenetic Map8q11UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)813442354Rat
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124608226Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125942267Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:32
Count of miRNA genes:30
Interacting mature miRNAs:32
Transcripts:ENSRNOT00000046058
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 5 8 2 2 12 2 4 8 2
Low 41 29 18 11 18 6 6 62 32 37 3 6
Below cutoff 2 2 23 23 23 3 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000046058   ⟹   ENSRNOP00000040361
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl8408,001 - 899,974 (+)Ensembl
RefSeq Acc Id: NM_023956   ⟹   NP_076446
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28500,212 - 889,203 (+)NCBI
Rnor_6.08408,001 - 899,851 (+)NCBI
Rnor_5.08417,520 - 903,360 (+)NCBI
RGSC_v3.48113,253 - 262,544 (+)RGD
Celera8386,346 - 771,749 (+)RGD
Sequence:
RefSeq Acc Id: XM_039082124   ⟹   XP_038938052
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28500,604 - 608,248 (+)NCBI
RefSeq Acc Id: XM_039082125   ⟹   XP_038938053
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28500,604 - 900,201 (+)NCBI
RefSeq Acc Id: XM_039082126   ⟹   XP_038938054
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28500,212 - 900,201 (+)NCBI
RefSeq Acc Id: XM_039082127   ⟹   XP_038938055
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28500,604 - 900,201 (+)NCBI
RefSeq Acc Id: XM_039082128   ⟹   XP_038938056
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28530,906 - 608,247 (+)NCBI
RefSeq Acc Id: XM_039082129   ⟹   XP_038938057
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28500,604 - 597,383 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_076446   ⟸   NM_023956
- UniProtKB: Q9WVI4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000040361   ⟸   ENSRNOT00000046058
RefSeq Acc Id: XP_038938054   ⟸   XM_039082126
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038938055   ⟸   XM_039082127
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038938053   ⟸   XM_039082125
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038938052   ⟸   XM_039082124
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038938057   ⟸   XM_039082129
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038938056   ⟸   XM_039082128
- Peptide Label: isoform X4
Protein Domains
Guanylate cyclase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621655 AgrOrtholog
Ensembl Genes ENSRNOG00000029876 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000040361 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000046058 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.450.260 UniProtKB/Swiss-Prot
  3.30.70.1230 UniProtKB/Swiss-Prot
  3.90.1520.10 UniProtKB/Swiss-Prot
InterPro A/G_cyclase UniProtKB/Swiss-Prot
  A/G_cyclase_CS UniProtKB/Swiss-Prot
  H-NOX_domain_sf UniProtKB/Swiss-Prot
  Heme_NO-bd UniProtKB/Swiss-Prot
  HNOB_dom_associated UniProtKB/Swiss-Prot
  HNOB_dom_associated_sf UniProtKB/Swiss-Prot
  NO_sig/Golgi_transp_ligand-bd UniProtKB/Swiss-Prot
  Nucleotide_cyclase UniProtKB/Swiss-Prot
KEGG Report rno:66012 UniProtKB/Swiss-Prot
NCBI Gene 66012 ENTREZGENE
Pfam Guanylate_cyc UniProtKB/Swiss-Prot
  HNOB UniProtKB/Swiss-Prot
  HNOBA UniProtKB/Swiss-Prot
PhenoGen Gucy1a2 PhenoGen
PROSITE GUANYLATE_CYCLASE_1 UniProtKB/Swiss-Prot
  GUANYLATE_CYCLASE_2 UniProtKB/Swiss-Prot
SMART CYCc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF111126 UniProtKB/Swiss-Prot
  SSF55073 UniProtKB/Swiss-Prot
UniProt GCYA2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q54A43 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-29 Gucy1a2  guanylate cyclase 1 soluble subunit alpha 2  Gucy1a2  guanylate cyclase 1, soluble, alpha 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-04-17 Gucy1a2  guanylate cyclase 1, soluble, alpha 2  LOC497842  similar to guanylate cyclase 1, soluble, alpha 2  Data Merged 737654 PROVISIONAL
2006-11-19 LOC497842  similar to guanylate cyclase 1, soluble, alpha 2      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Gucy1a2  guanylate cyclase 1, soluble, alpha 2    soluble guanylyl cyclase alpha2 subunit  Name updated 1299863 APPROVED
2002-08-07 Gucy1a2  soluble guanylyl cyclase alpha2 subunit      Symbol and Name status set to provisional 70820 PROVISIONAL