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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621632
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Itga2
Name: integrin subunit alpha 2
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Itga2affects expressionISOITGA2 (Homo sapiens)6480464CTDEstradiol affects the expression of ITGA2 mRNAPMID:22574217
Itga2increases expressionISOITGA2 (Homo sapiens)6480464CTDEstradiol results in increased expression of ITGA2 mRNA; Estradiol results in increased expression of ITGA2 proteinPMID:16912569 PMID:19619570 PMID:21185374 PMID:31614463
Itga2multiple interactionsISOITGA2 (Homo sapiens)6480464CTD[Estradiol co-treated with Progesterone] results in decreased expression of ITGA2 mRNA; [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ITGA2 mRNA; [Estradiol co-treated with TGFB1 protein] results in increased expression of ITGA2 mRNAPMID:19619570 PMID:20660070 PMID:30165855
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