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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621598
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lonp1
Name: lon peptidase 1, mitochondrial
Acc ID: CHEBI:85994
Term: lenvatinib
Definition: A member of the class of quinolines that is the carboxamide of 4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxylic acid. A multi-kinase inhibitor and orphan drug used (as its mesylate salt) for the treatment of various types of thyroid cancer that do not respond to radioiodine.
Chemical ID: MESH:C531958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lonp1decreases expressionEXP 6480464CTDlenvatinib results in decreased expression of LONP1 proteinPMID:34019861
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