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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621584
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tpp2
Name: tripeptidyl peptidase 2
Acc ID: CHEBI:4911
Term: etoposide
Definition: A furonaphthodioxole that has formula C29H32O13.
Chemical ID: MESH:D005047
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tpp2affects localizationISOTPP2 (Homo sapiens)6480464CTDEtoposide affects the localization of TPP2 proteinPMID:20643100
Tpp2affects localizationISOTpp2 (Mus musculus)6480464CTDEtoposide affects the localization of TPP2 proteinPMID:20643100
Tpp2multiple interactionsISOTPP2 (Homo sapiens)6480464CTD4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Etoposide affects the localization of TPP2 protein]; SB 203580 inhibits the reaction [Etoposide affects the localization of TPP2 protein]; U 0126 inhibits the reaction [Etoposide affects the localization of TPP2 protein]PMID:20643100
Tpp2multiple interactionsISOTpp2 (Mus musculus)6480464CTD4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Etoposide affects the localization of TPP2 protein]; Sirolimus promotes the reaction [Etoposide affects the localization of TPP2 protein]; U 0126 inhibits the reaction [Etoposide affects the localization of TPP2 protein]; wortmannin promotes the reaction [Etoposide affects the localization of TPP2 protein]PMID:20643100
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