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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621509
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ctsb
Name: cathepsin B
Acc ID: CHEBI:9367
Term: swainsonine
Definition: An indolizidine alkaloid isolated from the plant Swainsona canescens with three hydroxy substituents at positions 1, 2 and 8.
Chemical ID: MESH:D017026
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ctsbdecreases expressionEXP 6480464CTDSwainsonine results in decreased expression of CTSB proteinPMID:38579922
Ctsbincreases expressionEXP 6480464CTDSwainsonine results in increased expression of CTSB mRNAPMID:38579922
Ctsbmultiple interactionsEXP 6480464CTDTrehalose inhibits the reaction [Swainsonine results in decreased expression of CTSB protein]PMID:38579922
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