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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621506
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk8
Name: mitogen-activated protein kinase 8
Acc ID: CHEBI:5864
Term: ifosfamide
Definition: The simplest member of the class of ifosfamides that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by 2-chloroethyl groups on both the nitrogen atoms respectively. It is a nitrogen mustard alkylating agent used in the treatment of advanced breast cancer.
Chemical ID: MESH:D007069
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk8increases activityEXP 6480464CTDIfosfamide results in increased activity of MAPK8 proteinPMID:31722249
Mapk8multiple interactionsEXP 6480464CTDmorin inhibits the reaction [Ifosfamide results in increased activity of MAPK8 protein]PMID:31722249
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