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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62150
Species: Mus musculus
RGD Object: Gene
Symbol: Grk4
Name: G protein-coupled receptor kinase 4
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Grk4affects expressionISOGRK4 (Homo sapiens)6480464CTDValproic Acid affects the expression of GRK4 mRNAPMID:25979313
Grk4increases expressionISOGRK4 (Homo sapiens)6480464CTDValproic Acid results in increased expression of GRK4 mRNAPMID:32623605
Grk4multiple interactionsISOGRK4 (Homo sapiens)6480464CTD[Hydralazine co-treated with Valproic Acid] results in increased expression of GRK4 mRNA; CEBPA protein affects the reaction [Valproic Acid results in increased expression of GRK4 mRNA]PMID:17183730 PMID:32623605
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