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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621462
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Macroh2a1
Name: macroH2A.1 histone
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Macroh2a1increases expressionEXP 6480464CTDbisphenol A results in increased expression of MACROH2A1 mRNAPMID:25181051 PMID:30816183 PMID:32528016
Macroh2a1decreases methylationISOMACROH2A1 (Homo sapiens)6480464CTDbisphenol A results in decreased methylation of MACROH2A1 genePMID:31601247
Macroh2a1increases expressionISOMACROH2A1 (Homo sapiens)6480464CTDbisphenol A results in increased expression of MACROH2A1 proteinPMID:37567409
Macroh2a1increases expressionISOMacroh2a1 (Mus musculus)6480464CTDbisphenol A results in increased expression of MACROH2A1 mRNAPMID:26063408
Macroh2a1multiple interactionsISOMACROH2A1 (Homo sapiens)6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of MACROH2A1 mRNAPMID:28628672
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