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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621461
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ngb
Name: neuroglobin
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ngbdecreases expressionISONGB (Homo sapiens)6480464CTDDiethylhexyl Phthalate results in decreased expression of NGB mRNAPMID:25068794
Ngbincreases expressionISONgb (Mus musculus)6480464CTDDiethylhexyl Phthalate results in increased expression of NGB proteinPMID:28934723
Ngbmultiple interactionsISONGB (Homo sapiens)6480464CTDDiethylhexyl Phthalate inhibits the reaction [SP3 protein binds to NGB promoter]; MC1568 inhibits the reaction [Diethylhexyl Phthalate inhibits the reaction [SP3 protein binds to NGB promoter]]; MC1568 inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of NGB mRNA]PMID:25068794
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