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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621441
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ehhadh
Name: enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
Acc ID: CHEBI:47612
Term: bezafibrate
Definition: A monocarboxylic acid amide obtained by the formal condensation of the carboxy group of 4-chlorobenzoic acid with the amino group of 2-[4-(2-aminoethyl)phenoxy]-2-methylpropanoic acid. Benafibrate is used for the treatment of hyperlipidaemia.
Chemical ID: MESH:D001629
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ehhadhaffects expressionEXP 6480464CTDBezafibrate affects the expression of EHHADH mRNAPMID:17719200
Ehhadhincreases expressionISOEhhadh (Mus musculus)6480464CTDBezafibrate results in increased expression of EHHADH mRNA; Bezafibrate results in increased expression of EHHADH proteinPMID:12782154 PMID:17118139 PMID:19124612
Ehhadhmultiple interactionsISOEhhadh (Mus musculus)6480464CTDPPARA protein affects the reaction [Bezafibrate results in increased expression of EHHADH protein]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of EHHADH mRNA]PMID:12782154 PMID:19124612
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