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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621414
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kcnh2
Name: potassium voltage-gated channel subfamily H member 2
Acc ID: CHEBI:52172
Term: nilotinib
Definition: A carboxamide that has formula C28H22F3N7O.
Chemical ID: MESH:C498826
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnh2decreases activityISOKCNH2 (Homo sapiens)6480464CTDnilotinib results in decreased activity of KCNH2 proteinPMID:23707608
Kcnh2decreases expressionISOKCNH2 (Homo sapiens)6480464CTDnilotinib results in decreased expression of KCNH2 protein modified formPMID:35680041
Kcnh2multiple interactionsISOKCNH2 (Homo sapiens)6480464CTDN-butanoylsphingosine inhibits the reaction [nilotinib results in decreased expression of KCNH2 protein modified form]; nilotinib results in decreased expression of and results in decreased activity of KCNH2 proteinPMID:35680041
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