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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621414
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kcnh2
Name: potassium voltage-gated channel subfamily H member 2
Acc ID: CHEBI:49960
Term: vandetanib
Definition: A quinazoline that is 7-[(1-methylpiperidin-4-yl)methoxy]quinazoline bearing additional methoxy and 4-bromo-2-fluorophenylamino substituents at positions 6 and 4 respectively. Used for the treatment of symptomatic or progressive medullary thyroid cancer in patients with unresectable locally advanced or metastatic disease.
Chemical ID: MESH:C452423
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnh2affects bindingISOKCNH2 (Homo sapiens)6480464CTDvandetanib binds to KCNH2 proteinPMID:29630634
Kcnh2decreases expressionISOKCNH2 (Homo sapiens)6480464CTDvandetanib results in decreased expression of KCNH2 protein modified formPMID:35680041
Kcnh2multiple interactionsISOKCNH2 (Homo sapiens)6480464CTDBrefeldin A promotes the reaction [vandetanib results in decreased expression of KCNH2 protein modified form]; N-butanoylsphingosine inhibits the reaction [vandetanib results in decreased expression of KCNH2 protein modified form]; vandetanib results in decreased expression of and results in decreased activity of KCNH2 proteinPMID:35680041
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