GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Kcnh2 | decreases activity | ISO | KCNH2 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in decreased activity of KCNH2 protein | PMID:25107562 | Kcnh2 | decreases expression | ISO | KCNH2 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in decreased expression of KCNH2 protein | PMID:22977528 | Kcnh2 | decreases localization | ISO | KCNH2 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in decreased localization of KCNH2 protein | PMID:15213294 PMID:23103450 | Kcnh2 | increases degradation | ISO | KCNH2 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in increased degradation of KCNH2 protein | PMID:28521025 | Kcnh2 | increases expression | ISO | KCNH2 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in increased expression of KCNH2 mRNA | PMID:15070760 | Kcnh2 | multiple interactions | ISO | KCNH2 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide affects the expression of and results in increased activity of KCNH2 protein; Arsenic Trioxide results in decreased expression of and affects the localization of and results in decreased activity of KCNH2 protein; Astemizole inhibits the reaction [Arsenic Trioxide results in increased degradation of KCNH2 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Arsenic Trioxide results in increased degradation of KCNH2 protein]; fexofenadine inhibits the reaction [Arsenic Trioxide results in increased degradation of KCNH2 protein]; Matrines inhibits the reaction [Arsenic Trioxide results in decreased localization of KCNH2 protein]; MIR21 mRNA promotes the reaction [Arsenic Trioxide results in decreased expression of KCNH2 protein]; MIR23A mRNA promotes the reaction [Arsenic Trioxide results in decreased expression of and affects the localization of and results in decreased activity of KCNH2 protein]; oxymatrine inhibits the reaction [Arsenic Trioxide results in decreased localization of KCNH2 protein]; Ranolazine inhibits the reaction [Arsenic Trioxide results in increased degradation of KCNH2 protein]; Resveratrol inhibits the reaction [Arsenic Trioxide results in decreased activity of KCNH2 protein] | PMID:23103450 PMID:25107562 PMID:25395240 PMID:28521025 PMID:30127993 | | ||||||||||||||||||||||
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