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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621400
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1i3
Name: nuclear receptor subfamily 1, group I, member 3
Acc ID: CHEBI:34687
Term: dibutyl phthalate
Definition: A phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol. Although used extensively as a plasticiser, it is a ubiquitous environmental contaminant that poses a risk to humans.
Chemical ID: MESH:D003993
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i3increases activityEXP 6480464CTDDibutyl Phthalate results in increased activity of NR1I3 proteinPMID:15901914
Nr1i3affects bindingISONR1I3 (Homo sapiens)6480464CTDDibutyl Phthalate analog binds to NR1I3 proteinPMID:25938866
Nr1i3increases activityISONR1I3 (Homo sapiens)6480464CTDDibutyl Phthalate results in increased activity of NR1I3 protein; Dibutyl Phthalate results in increased activity of NR1I3 protein alternative formPMID:21227907 PMID:28927721
Nr1i3multiple interactionsISONR1I3 (Homo sapiens)6480464CTD[Dibutyl Phthalate co-treated with Androstanols] results in increased activity of NR1I3 protein alternative formPMID:21227907
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