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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621316
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:16136
Term: hydrogen sulfide
Definition: A sulfur hydride consisting of a single sulfur atom bonded to two hydrogen atoms. A highly poisonous, flammable gas with a characteristic odour of rotten eggs, it is often produced by bacterial decomposition of organic matter in the absence of oxygen.
Chemical ID: MESH:D006862
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp2increases expressionEXP 6480464CTDHydrogen Sulfide results in increased expression of MMP2 mRNA; Hydrogen Sulfide results in increased expression of MMP2 proteinPMID:24722316
Mmp2multiple interactionsEXP 6480464CTDDexamethasone inhibits the reaction [Hydrogen Sulfide results in increased expression of MMP2 mRNA]; Dexamethasone inhibits the reaction [Hydrogen Sulfide results in increased expression of MMP2 protein]; Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [Hydrogen Sulfide results in increased expression of MMP2 mRNA]]; Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [Hydrogen Sulfide results in increased expression of MMP2 protein]]PMID:24722316
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