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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621168
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ogg1
Name: 8-oxoguanine DNA glycosylase
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ogg1increases expressionEXP 6480464CTDCadmium Chloride results in increased expression of OGG1 mRNAPMID:30606898
Ogg1decreases expressionISOOGG1 (Homo sapiens)6480464CTDCadmium Chloride results in decreased expression of OGG1 mRNA; Cadmium Chloride results in decreased expression of OGG1 proteinPMID:22112500 PMID:26472689
Ogg1increases methylationISOOGG1 (Homo sapiens)6480464CTDCadmium Chloride results in increased methylation of OGG1 promoterPMID:22112500
Ogg1multiple interactionsISOOGG1 (Homo sapiens)6480464CTD[Cadmium Chloride co-treated with titanium dioxide] results in increased expression of OGG1 mRNA; [Cadmium Chloride results in increased activity of [DNMT1 protein co-treated with DNMT3A protein]] which results in decreased expression of OGG1 mRNA; [Cadmium Chloride results in increased activity of [DNMT1 protein co-treated with DNMT3A protein]] which results in increased methylation of OGG1 promoter; decitabine inhibits the reaction [Cadmium Chloride results in decreased expression of OGG1 mRNA]; decitabine inhibits the reaction [Cadmium Chloride results in decreased expression of OGG1 protein]PMID:21671166 PMID:22112500
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