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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621117
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nlgn1
Name: neuroligin 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nlgn1affects methylationISONLGN1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of NLGN1 5' UTR; Benzo(a)pyrene affects the methylation of NLGN1 intron; Benzo(a)pyrene affects the methylation of NLGN1 promoterPMID:27901495 PMID:30157460
Nlgn1decreases expressionISONLGN1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of NLGN1 mRNAPMID:20106945
Nlgn1decreases methylationISONLGN1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of NLGN1 3' UTRPMID:27901495
Nlgn1increases mutagenesisISONLGN1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased mutagenesis of NLGN1 genePMID:25435355
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