Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	62109
Species:	Mus musculus
RGD Object:	Gene
Symbol:	Col1a1
Name:	collagen, type I, alpha 1

Acc ID:	CHEBI:27573
Term:	silicon atom
Definition:	A carbon group element atom that has formula Si.
Chemical ID:	MESH:D012825

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Col1a1	increases expression	EXP		6480464	CTD	Silicon results in increased expression of COL1A1 mRNA	PMID:34252510
Col1a1	multiple interactions	EXP		6480464	CTD	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Silicon Dioxide results in increased abundance of Silicon] which results in increased expression of COL1A1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Silicon Dioxide results in increased abundance of Silicon] which results in increased expression of COL1A1 protein]; [Silicon Dioxide results in increased abundance of Silicon] which results in increased expression of COL1A1 mRNA; [Silicon Dioxide results in increased abundance of Silicon] which results in increased expression of COL1A1 protein; Thioctic Acid inhibits the reaction [Silicon results in increased expression of COL1A1 mRNA]	PMID:34252510 PMID:39353502

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