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GENE - TERM ANNOTATION REPORT

RGD ID: 621081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tgm2
Name: transglutaminase 2
Acc ID: GO:0007200
Term: phospholipase C-activating G protein-coupled receptor signaling pathway
Definition: A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). IP3 regulates the opening of calcium channels in intracellular calcium store, leading to the release of calcium into the cytosol. Calcium and DAG activate protein kinase C (PKC), which in turn activates downstream effectors.
Definition Source(s): GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgm2involved_inISOTGM2 (Homo sapiens)1624291RGD PMID:7592956 PMID:8943303

PMID:7592956 PMID:8943303
Tgm2involved_inIEAUniProtKB:P21980 or ensembl:ENSP000003553301600115EnsemblGO_REF:0000107

GO_REF:0000107
Tgm2involved_inIBAPANTHER:PTN008521254 or Tgm2 (Rattus norvegicus) or UniProtKB:P219801600115GO_CentralGO_REF:0000033

GO_REF:0000033
Tgm2acts_upstream_of_or_withinIDA 8553754MGIPMID:7911253

 
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