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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tgm2
Name: transglutaminase 2
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgm2multiple interactionsISOTGM2 (Homo sapiens)6480464CTD[Hexylresorcinol results in decreased activity of TGM2 protein] which results in increased susceptibility to CisplatinPMID:21424127
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