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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621074
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sfrp1
Name: secreted frizzled-related protein 1
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sfrp1decreases methylationISOSFRP1 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased methylation of SFRP1 gene; Arsenic Trioxide results in decreased methylation of SFRP1 promoterPMID:26966376 PMID:28565807
Sfrp1increases expressionISOSFRP1 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of SFRP1 mRNA; Arsenic Trioxide results in increased expression of SFRP1 proteinPMID:26966376 PMID:28565807
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