Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621069
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rest
Name: RE1-silencing transcription factor
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Restmultiple interactionsEXP 6480464CTDJUN protein promotes the reaction [resveratrol inhibits the reaction [2,2',3,5',6-pentachlorobiphenyl results in increased expression of REST mRNA]]; JUN protein promotes the reaction [resveratrol inhibits the reaction [2,2',3,5',6-pentachlorobiphenyl results in increased expression of REST protein]]; resveratrol inhibits the reaction [2,2',3,5',6-pentachlorobiphenyl results in increased expression of REST mRNA]; resveratrol inhibits the reaction [2,2',3,5',6-pentachlorobiphenyl results in increased expression of REST protein]; SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [2,2',3,5',6-pentachlorobiphenyl results in increased expression of REST mRNA]]; SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [2,2',3,5',6-pentachlorobiphenyl results in increased expression of REST protein]]PMID:26307266
Restdecreases expressionISOREST (Homo sapiens)6480464CTDresveratrol results in decreased expression of REST mRNA; resveratrol results in decreased expression of REST proteinPMID:26307266
Restmultiple interactionsISOREST (Homo sapiens)6480464CTD6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol promotes the reaction [JUN protein binds to REST promoter]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol results in decreased expression of REST mRNA]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol results in decreased expression of REST protein]; JUN protein promotes the reaction [resveratrol results in decreased expression of REST mRNA]; JUN protein promotes the reaction [resveratrol results in decreased expression of REST protein]; resveratrol inhibits the reaction [2,2',3,5',6-pentachlorobiphenyl results in increased expression of REST mRNA]; resveratrol inhibits the reaction [2,2',3,5',6-pentachlorobiphenyl results in increased expression of REST protein]; resveratrol promotes the reaction [JUN protein modified form binds to REST promoter]; SIRT1 protein promotes the reaction [resveratrol results in decreased expression of REST mRNA]; SIRT1 protein promotes the reaction [resveratrol results in decreased expression of REST protein]PMID:26307266
Go Back to source page   Continue to Ontology report