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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621057
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnc
Name: tenascin C
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tncincreases expressionISOTNC (Homo sapiens)6480464CTDOzone results in increased expression of TNC mRNAPMID:23033980
Tncincreases expressionISOTnc (Mus musculus)6480464CTDOzone results in increased expression of TNC mRNAPMID:19555225
Tncmultiple interactionsISOTNC (Homo sapiens)6480464CTD[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of TNC mRNA; [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of TNC mRNA; [Volatile Organic Compounds co-treated with Ozone] results in increased oxidation of TNC mRNAPMID:32699268
Tncmultiple interactionsISOTnc (Mus musculus)6480464CTD[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of TNC mRNA; [Air Pollutants results in increased abundance of Ozone] which results in increased expression of TNC mRNA; [NOTCH3 gene mutant form affects the susceptibility to Ozone] which affects the expression of TNC mRNA; TTPA protein affects the reaction [Ozone results in increased expression of TNC mRNA]PMID:19555225 PMID:25658374 PMID:27106289 PMID:34911549
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