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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621006
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atp6v0a2
Name: ATPase H+ transporting V0 subunit a2
Acc ID: CHEBI:7071
Term: N,N-diethyl-m-toluamide
Definition: A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of m-toluic acid with the nitrogen of diethylamine. First developed by the U.S. Army in 1946 for use by military personnel in insect-infested areas, it is the most widely used insect repellent worldwide.
Chemical ID: MESH:D003671
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atp6v0a2multiple interactionsEXP 6480464CTD[Permethrin co-treated with DEET] results in decreased methylation of ATP6V0A2 gene; [Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of ATP6V0A2 mRNAPMID:28659758 PMID:33148267
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