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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620995
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pde5a
Name: phosphodiesterase 5A
Acc ID: CHEBI:58987
Term: sildenafil citrate
Definition: The citrate salt of sildenafil.
Chemical ID: MESH:D000068677
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pde5adecreases activityEXP 6480464CTDSildenafil Citrate results in decreased activity of PDE5A proteinPMID:19374906
Pde5amultiple interactionsEXP 6480464CTD[Sildenafil Citrate co-treated with resveratrol] inhibits the reaction [Streptozocin results in increased expression of PDE5A protein]PMID:26006044
Pde5adecreases activityISOPDE5A (Homo sapiens)6480464CTDSildenafil Citrate results in decreased activity of PDE5A proteinPMID:10422958 PMID:15934858 PMID:16368379 PMID:17138653 PMID:18778098 PMID:8858389
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