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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620963
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Eif2s1
Name: eukaryotic translation initiation factor 2 subunit alpha
Acc ID: CHEBI:7852
Term: oxycodone
Definition: A semisynthetic opioid of formula C18H21NO4 that is derived from thebaine. It is a moderately potent opioid analgesic, generally used for relief of moderate to severe pain.
Chemical ID: MESH:D010098
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eif2s1increases phosphorylationEXP 6480464CTDOxycodone results in increased phosphorylation of EIF2S1 proteinPMID:26377394
Eif2s1increases phosphorylationISOEIF2S1 (Homo sapiens)6480464CTDOxycodone results in increased phosphorylation of EIF2S1 proteinPMID:26377394
Eif2s1multiple interactionsISOEIF2S1 (Homo sapiens)6480464CTDNaloxone inhibits the reaction [Oxycodone results in increased phosphorylation of EIF2S1 protein]PMID:26377394
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