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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620963
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Eif2s1
Name: eukaryotic translation initiation factor 2 subunit alpha
Acc ID: CHEBI:3687
Term: chrysophanol
Definition: A trihydroxyanthraquinone that is chrysazin with a methyl substituent at C-3. It has been isolated from Aloe vera and exhibits antiviral and anti-inflammatory activity.
Chemical ID: MESH:C027113
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eif2s1increases phosphorylationISOEIF2S1 (Homo sapiens)6480464CTDchrysophanic acid results in increased phosphorylation of EIF2S1 proteinPMID:30300626
Eif2s1multiple interactionsISOEIF2S1 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [chrysophanic acid results in increased phosphorylation of EIF2S1 protein]PMID:30300626
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