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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620959
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tdg
Name: thymine-DNA glycosylase
Acc ID: CHEBI:7719
Term: ochratoxin A
Definition: A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.
Chemical ID: MESH:C025589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tdgdecreases acetylationISOTDG (Homo sapiens)6480464CTDochratoxin A results in decreased acetylation of TDG promoterPMID:29098329
Tdgdecreases expressionISOTDG (Homo sapiens)6480464CTDochratoxin A results in decreased expression of TDG mRNAPMID:29098329
Tdgmultiple interactionsISOTDG (Homo sapiens)6480464CTD[ochratoxin A results in decreased acetylation of TDG promoter] which results in decreased expression of TDG mRNAPMID:29098329
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