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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62092
Species: Mus musculus
RGD Object: Gene
Symbol: Htr2a
Name: 5-hydroxytryptamine (serotonin) receptor 2A
Acc ID: CHEBI:31236
Term: aripiprazole
Definition: An N-arylpiperazine that is piperazine substituted by a 4-[(2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)oxy]butyl group at position 1 and by a 2,3-dichlorophenyl group at position 4. It is an antipsychotic drug used for the treatment of Schizophrenia, and other mood disorders.
Chemical ID: MESH:C094645
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Htr2aaffects response to substanceISOHTR2A (Homo sapiens)6480464CTDHTR2A protein affects the susceptibility to AripiprazolePMID:16314884
Htr2adecreases response to substanceISOHTR2A (Homo sapiens)6480464CTDHTR2A gene SNP results in decreased susceptibility to AripiprazolePMID:16314884
Htr2amultiple interactionsISOHTR2A (Homo sapiens)6480464CTDAripiprazole binds to and results in decreased activity of HTR2A protein; Aripiprazole binds to and results in increased activity of HTR2A protein; Aripiprazole inhibits the reaction [Ketanserin binds to HTR2A protein]PMID:16314884 PMID:21823597
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