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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620907
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ppp2r1a
Name: protein phosphatase 2 scaffold subunit A alpha
Acc ID: CHEBI:27656
Term: camptothecin
Definition: A pyranoindolizinoquinoline that is pyrano[3',4':6,7]indolizino[1,2-b]quinoline which is substituted by oxo groups at positions 3 and 14, and by an ethyl group and a hydroxy group at position 4 (the S enantiomer).
Chemical ID: MESH:D002166
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppp2r1aaffects localizationISOPPP2R1A (Homo sapiens)6480464CTDCamptothecin affects the localization of PPP2R1A proteinPMID:25772433
Ppp2r1adecreases response to substanceISOPPP2R1A (Homo sapiens)6480464CTDPPP2R1A mRNA results in decreased susceptibility to CamptothecinPMID:25269479
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