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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620899
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pik3c3
Name: phosphatidylinositol 3-kinase, catalytic subunit type 3
Acc ID: CHEBI:81520
Term: 2,3',4,4',5-Pentachlorobiphenyl
Definition: A pentachlorobiphenyl that has formula C12H5Cl5.
Chemical ID: MESH:C070055
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pik3c3decreases expressionEXP 6480464CTD2,3',4,4',5-pentachlorobiphenyl results in decreased expression of PIK3C3 mRNAPMID:31020377
Pik3c3increases phosphorylationEXP 6480464CTD2,3',4,4',5-pentachlorobiphenyl results in increased phosphorylation of PIK3C3 proteinPMID:31020377
Pik3c3multiple interactionsEXP 6480464CTDDAPK2 protein affects the reaction [2,3',4,4',5-pentachlorobiphenyl results in increased phosphorylation of PIK3C3 protein]; PRKD1 protein affects the reaction [2,3',4,4',5-pentachlorobiphenyl results in increased phosphorylation of PIK3C3 protein]; TUBB3 protein promotes the reaction [2,3',4,4',5-pentachlorobiphenyl results in increased phosphorylation of PIK3C3 protein]PMID:31020377
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