GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Zfp36 | increases activity | ISO | ZFP36 (Homo sapiens) | 6480464 | CTD | Nicotine results in increased activity of ZFP36 promoter | PMID:21606497 | Zfp36 | increases expression | ISO | Zfp36 (Mus musculus) | 6480464 | CTD | Nicotine results in increased expression of ZFP36 mRNA; Nicotine results in increased expression of ZFP36 protein | PMID:22093924 PMID:24095726 | Zfp36 | increases response to substance | ISO | Zfp36 (Mus musculus) | 6480464 | CTD | ZFP36 protein results in increased susceptibility to Nicotine | PMID:22093924 PMID:24095726 | Zfp36 | multiple interactions | ISO | ZFP36 (Homo sapiens) | 6480464 | CTD | [Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 mRNA; [Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 protein; Bungarotoxins inhibits the reaction [[Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 mRNA]; methyllycaconitine inhibits the reaction [[Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 mRNA]; Nicotine promotes the reaction [STAT3 protein binds to ZFP36 promoter]; ZFP36 mRNA affects the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; ZFP36 mRNA affects the reaction [Nicotine results in increased degradation of TNF mRNA] | PMID:21606497 | Zfp36 | multiple interactions | ISO | Zfp36 (Mus musculus) | 6480464 | CTD | [Lipopolysaccharides co-treated with Nicotine] results in increased expression of ZFP36 mRNA; HMOX1 protein promotes the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of ZFP36 mRNA]; HMOX1 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of ZFP36 mRNA]]; HMOX1 protein promotes the reaction [Nicotine results in increased expression of ZFP36 mRNA]; STAT3 protein promotes the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of ZFP36 mRNA]; STAT3 protein promotes the reaction [Nicotine results in increased expression of ZFP36 mRNA]; tin protoporphyrin IX inhibits the reaction [Nicotine results in increased expression of ZFP36 mRNA]; ZFP36 mutant form inhibits the reaction [Nicotine results in decreased expression of CCL2 mRNA]; ZFP36 mutant form inhibits the reaction [Nicotine results in decreased expression of IL6 mRNA]; ZFP36 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; ZFP36 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; ZFP36 protein promotes the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; zinc protoporphyrin inhibits the reaction [[Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 mRNA]; zinc protoporphyrin inhibits the reaction [Nicotine results in increased expression of ZFP36 mRNA] | PMID:22093924 PMID:24095726 | | ||||||||||||||||||||||
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